Focus on mechano-immunology: new direction in cancer treatment DOI Creative Commons
Lin Zhao,

Yajun Gui,

Xiangying Deng

et al.

International Journal of Surgery, Journal Year: 2025, Volume and Issue: 111(3), P. 2590 - 2602

Published: Jan. 7, 2025

The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance

Language: Английский

Focus on mechano-immunology: new direction in cancer treatment DOI Creative Commons
Lin Zhao,

Yajun Gui,

Xiangying Deng

et al.

International Journal of Surgery, Journal Year: 2025, Volume and Issue: 111(3), P. 2590 - 2602

Published: Jan. 7, 2025

The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance

Language: Английский

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