Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(23), P. 7198 - 7198
Published: Nov. 27, 2024
Background/Objectives:
Chronic
liver
disease
(CLD)
is
highly
relevant
in
clinical
practice
due
to
its
increasing
incidence
and
associated
mortality.
We
aimed
exhaustively
characterize
the
multimorbidity
of
patients
with
CLD.
Methods:
This
a
retrospective
observational
study
aged
18
years
older
diagnosis
CLD
2015
EpiChron
Cohort
(Spain).
analyzed
prevalence
comorbidities
according
sex
age,
conducted
logistic
regression
analysis
as
independent
variable
each
dependent
variables
obtain
odds
ratios
(OR)
adjusted
for
age
sex,
performed
an
exploratory
factor
identify
presence
patterns.
Results:
A
total
6836
adults
had
(mean
61.6
years;
62.5%
women),
average
13
co-existing
chronic
conditions.
Arterial
hypertension,
lipid
metabolism
disorders,
diabetes,
obesity,
musculoskeletal
diseases
were
most
frequent
diseases.
From
list
110
conditions
analyzed,
75
systematically
CLD,
including
(OR,
95%
confidence
interval)
pancreatitis
(41.2,
33.5–50.6)
inherited
metabolic
disorders
(14.9,
11.8–18.8).
Three
patterns
identified
both
men
women,
cardiovascular,
metabolic-geriatric,
mental-substance
use,
some
differences
by
sex.
Conclusions:
Multimorbidity
norm
Our
results
reveal
that
comprehensive
integral
approach
based
on
person-centered
care,
which
should
take
into
account
their
entire
spectrum
multimorbidity,
necessary
during
care
this
type
patient
practice.
Hepatoma Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Hepatocellular
carcinoma
(HCC)
ranks
as
the
third
leading
cause
of
cancer-related
deaths
worldwide.
It
presents
a
significant
and
rising
global
health
challenge
due
to
its
complex
development,
high
mortality
rate,
poor
prognosis.
The
primary
treatment
methods
include
chemotherapy,
radiotherapy,
surgery,
yet
each
is
associated
with
severe
side
effects.
While
combination
therapies
can
enhance
outcomes,
they
also
tend
amplify
adverse
For
this
reason,
prevention
HCC
has
major
impact
on
world
health.
Current
knowledge
indicates
that
healthy
lifestyle
combined
diet
an
excellent
preventive
strategy.
In
respect,
Mediterranean
represents
valid
strategy
widely
recognized
by
scientific
community.
Its
effectiveness
proven
presence
several
polyphenols
in
main
foods,
including
quercetin,
luteolin,
myricetin,
kaempferol.
These
are
present
different
functional
foods
show
anticancer
activity.
This
narrative
review
aims
assess
anti-HCC
activity
these
characterize
diet.
Livers,
Journal Year:
2024,
Volume and Issue:
4(4), P. 495 - 506
Published: Sept. 30, 2024
The
primary
objective
of
modern
medicine
is
to
extend
human
life
expectancy.
Currently,
the
majority
hospital
patients
across
various
clinical
settings
are
elderly
or
advanced-age
individuals,
often
with
multiple
comorbidities
and
age-related
alterations
in
peripheral
tissues.
One
such
alteration
sarcopenia,
a
progressive
decline
muscle
mass,
strength,
function,
which
significantly
increases
risk
disability
mortality
older
adults.
Sarcopenia
associated
numerous
adverse
outcomes,
its
underlying
mechanisms
subject
ongoing
research.
This
narrative
review
discusses
epidemiology,
pathophysiology,
diagnostic
criteria
for
sarcopenia.
It
also
examines
connections
between
sarcopenia
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
highlighting
potential
treatment
approaches
coexistence
these
two
pathologies.
Digestive and Liver Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Fatty
acid
esters
of
hydroxy
fatty
acids
(FAHFAs)
present
potential
beneficial
effects
that
could
offer
valuable
insights
into
metabolic
and
inflammatory
diseases.
However,
few
FAHFAs
have
been
studied,
their
role
is
unclear.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(23), P. 7198 - 7198
Published: Nov. 27, 2024
Background/Objectives:
Chronic
liver
disease
(CLD)
is
highly
relevant
in
clinical
practice
due
to
its
increasing
incidence
and
associated
mortality.
We
aimed
exhaustively
characterize
the
multimorbidity
of
patients
with
CLD.
Methods:
This
a
retrospective
observational
study
aged
18
years
older
diagnosis
CLD
2015
EpiChron
Cohort
(Spain).
analyzed
prevalence
comorbidities
according
sex
age,
conducted
logistic
regression
analysis
as
independent
variable
each
dependent
variables
obtain
odds
ratios
(OR)
adjusted
for
age
sex,
performed
an
exploratory
factor
identify
presence
patterns.
Results:
A
total
6836
adults
had
(mean
61.6
years;
62.5%
women),
average
13
co-existing
chronic
conditions.
Arterial
hypertension,
lipid
metabolism
disorders,
diabetes,
obesity,
musculoskeletal
diseases
were
most
frequent
diseases.
From
list
110
conditions
analyzed,
75
systematically
CLD,
including
(OR,
95%
confidence
interval)
pancreatitis
(41.2,
33.5–50.6)
inherited
metabolic
disorders
(14.9,
11.8–18.8).
Three
patterns
identified
both
men
women,
cardiovascular,
metabolic-geriatric,
mental-substance
use,
some
differences
by
sex.
Conclusions:
Multimorbidity
norm
Our
results
reveal
that
comprehensive
integral
approach
based
on
person-centered
care,
which
should
take
into
account
their
entire
spectrum
multimorbidity,
necessary
during
care
this
type
patient
practice.
