Ferroptosis in Cancer: Mechanism and Therapeutic Potential DOI Open Access
Manish Kumar Singh,

H Arora,

Rutuja Naik

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3852 - 3852

Published: April 18, 2025

Cancer drug resistance occurs when cancer cells evade cell death following treatment with chemotherapy, radiation therapy, and targeted therapies. This is often linked to the reprogramming of programmed (PCD) pathways, allowing survive drug-induced stress. However, certain anticancer therapies, combined specific agents or inhibitors, can induce ferroptosis—a form driven by iron-dependent lipid peroxidation. Currently, extensive preclinical clinical research underway investigate molecular, cellular, tissue-specific mechanisms underlying ferroptosis, goal identifying strategies overcome in cancers unresponsive conventional PCD pathways. By harnessing be compelled undergo peroxidation-induced death, potentially improving therapeutic outcomes patients cancer. short review aims enhance understanding ferroptosis inducers therapy stimulate further into ferroptosis-based approaches for more effective treatment.

Language: Английский

Ferroptosis in Cancer: Mechanism and Therapeutic Potential DOI Open Access
Manish Kumar Singh,

H Arora,

Rutuja Naik

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3852 - 3852

Published: April 18, 2025

Cancer drug resistance occurs when cancer cells evade cell death following treatment with chemotherapy, radiation therapy, and targeted therapies. This is often linked to the reprogramming of programmed (PCD) pathways, allowing survive drug-induced stress. However, certain anticancer therapies, combined specific agents or inhibitors, can induce ferroptosis—a form driven by iron-dependent lipid peroxidation. Currently, extensive preclinical clinical research underway investigate molecular, cellular, tissue-specific mechanisms underlying ferroptosis, goal identifying strategies overcome in cancers unresponsive conventional PCD pathways. By harnessing be compelled undergo peroxidation-induced death, potentially improving therapeutic outcomes patients cancer. short review aims enhance understanding ferroptosis inducers therapy stimulate further into ferroptosis-based approaches for more effective treatment.

Language: Английский

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