Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104774 - 104774
Published: May 1, 2025
Language: Английский
Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940
Published: March 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Language: Английский
Citations
2
Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)
Published: April 23, 2025
Cisplatin (DDP) resistance is a key factor hindering esophageal cancer (ESCA) treatment. Exosomes have been reported to confer DDP in various tumor cells. However, the effects of ESCA cell-derived exosomes and exosomal human antigen R (HuR) on cells not elucidated. In this study, isolated were identified by transmission electron microscopy, nanoparticle tracking analysis, western blotting. CCK-8 flow cytometry employed assess functional role DDP-resistant their parental Bioinformatics analysis was performed identify molecules that positively associated with HuR validated using dual-luciferase reporter RNA immunoprecipitation assays. We found from enhance drug-resistant DDP. Importantly, protein, but mRNA, directly transferred into via exosomes, thereby increasing level protein. Mechanistically, correlated Lamin B2 (LMNB2) cells, transfected siRNA targeting LMNB2 exhibited reduced cell viability elevated apoptosis rates. Moreover, vivo nude mouse model. Collectively, our results revealed exposed induced greater drug delivery. Targeting or its related target may present new therapeutic opportunities for treating patients ESCA.
Language: Английский
Citations
0
Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: April 29, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 685 - 685
Published: May 8, 2025
Chemotherapy resistance represents a formidable obstacle in oncological therapeutics, substantially compromising the efficacy of adjuvant chemotherapy regimens and contributing to unfavorable clinical prognoses. Emerging evidence has elucidated pivotal involvement exosomes dissemination chemoresistance phenotypes among tumor cells within microenvironment. This review delineates two distinct intra-tumoral mechanisms orchestrated by exosomes: (1) exosome-mediated sequestration chemotherapeutic agents coupled with enhanced drug efflux neoplastic cells, (2) horizontal transfer drug-sensitive through delivery bioactive molecular cargo, thereby facilitating propagation across population. Furthermore, covers current vivo experimental data focusing on targeted interventions against specific genetic elements exosomal secretion pathways, demonstrating their potential mitigating resistance. Additionally, therapeutic inhibiting transporter strategy is particularly examined as promising overcome mechanisms.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: May 15, 2025
Recent studies have promoted new insights into the biology of non-small cell lung cancer (NSCLC) and made considerable progress in field treatment, including targeted therapy for driver gene mutations. Immunotherapy (IO) is another breakthrough, which has achieved amazing clinical efficacy. However, survival status advanced NSCLC patients still unsatisfactory. Drug resistance an urgent problem to be solved almost all anti-cancer treatment schemes. Nowadays, platinum based chemotherapy remains standard with negative NSCLC. Previous shown that reduction intracellular accumulation drugs, DNA damage repair enhancement detoxification effect lead resistance. The mechanisms tyrosine kinase inhibitors (TKIs) include emergence secondary mutation, activation bypass signal pathways, abnormality downstream pathways transformation phenotype. immune checkpoint (ICIs) are more complex. A variety cells, cytokines metabolites participate it form immunosuppressive microenvironment, resulting impairment effector T function. Exosomes small molecules secreted by a cells. They can carry information such as miRNA, lncRNA, protein, play pivotal role transduction between More show exosomes important transmitters transfer drug from drug-resistant cells sensitive underling specific need further explored find breakthrough overcoming
Language: Английский
Citations
0
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104774 - 104774
Published: May 1, 2025
Language: Английский
Citations
0