The role of endosarcomeric cytoskeleton proteins in the mechanisms of left ventricular diastolic dysfunction: focus on titin DOI Creative Commons
V. V. Kalyuzhin, А. T. Teplyakov, И. Д. Беспалова

et al.

Bulletin of Siberian Medicine, Journal Year: 2023, Volume and Issue: 22(3), P. 98 - 109

Published: Oct. 18, 2023

Recognizing the fact that isolated left ventricular (LV) diastolic dysfunction (DD) underlies approximately 50% of all heart failure cases requires a deep understanding its principal mechanisms so effective diagnostic and treatment strategies can be developed. Despite abundance knowledge about underlying DD, many important questions regarding pathophysiology diastole remain unresolved. In particular, role endosarcomeric cytoskeleton pathology in deterioration so-called active (relaxation LV myocardium atrioventricular pressure gradient at beginning diastole, closely related to it healthy heart) passive (myocardial stiffness) characteristics needs clarified. The lecture briefly discusses complex hierarchy DD (from sarcomere whole covers giant protein titin latter, which is main determinant intracellular stiffness. Impairment myocardial relaxation wall compliance under wide range pathological conditions (pressure overload, ischemia, inflammation, cardiotoxic effects, oxidative stress, etc.) explained by shift expression toward more rigid N2B isoform, hypophosphorylation kinases A G or dephosphorylation serine / threonine phosphatase 5 molecule extensible segment containing unique sequence, hyperphosphorylation PEVK regions kinase C, as well inhibition Ca 2 +-dependent – actin interaction. results deciphering these become tool for developing new approaches targeted therapy currently does not have treatment, on one hand, key therapeutic effects drugs already used treat chronic with preserved ejection fraction, other hand.

Language: Английский

New draft classification of chronic heart failure of the Russian Society of Cardiology: are there any obvious advantages over the current ones? DOI Creative Commons
V. V. Kalyuzhin, А. T. Teplyakov, И. Д. Беспалова

et al.

Bulletin of Siberian Medicine, Journal Year: 2024, Volume and Issue: 23(1), P. 144 - 155

Published: April 11, 2024

In the interests of practical healthcare, routine classifications should be modified as rarely possible. At same time changes discarded only on sufficient grounds, for example, when there are no obvious advantages a new classification over existing ones or they can longer by introducing fundamental and amendments. this regard, evolution approaches to chronic heart failure (CHF) is prominent. It becomes particularly relevant due fact that currently experts Russian Society Cardiology (RSC) actively discussing draft CHF. The authors lecture gave brief historical insight reviewed main CHF used in North America, Europe, Russia. proposed RSC experts, which actually American colleagues, does not have Russia (since 2002). latter based Vasilenko – Strazhesko familiar domestic internists, since it has become an indispensable part their clinical practice stood test time. addition, its underlying principles provide potential flexible modification.

Language: Английский

Citations

1
The role of endosarcomeric cytoskeleton proteins in the mechanisms of left ventricular diastolic dysfunction: focus on titin DOI Creative Commons
V. V. Kalyuzhin, А. T. Teplyakov, И. Д. Беспалова

et al.

Bulletin of Siberian Medicine, Journal Year: 2023, Volume and Issue: 22(3), P. 98 - 109

Published: Oct. 18, 2023

Recognizing the fact that isolated left ventricular (LV) diastolic dysfunction (DD) underlies approximately 50% of all heart failure cases requires a deep understanding its principal mechanisms so effective diagnostic and treatment strategies can be developed. Despite abundance knowledge about underlying DD, many important questions regarding pathophysiology diastole remain unresolved. In particular, role endosarcomeric cytoskeleton pathology in deterioration so-called active (relaxation LV myocardium atrioventricular pressure gradient at beginning diastole, closely related to it healthy heart) passive (myocardial stiffness) characteristics needs clarified. The lecture briefly discusses complex hierarchy DD (from sarcomere whole covers giant protein titin latter, which is main determinant intracellular stiffness. Impairment myocardial relaxation wall compliance under wide range pathological conditions (pressure overload, ischemia, inflammation, cardiotoxic effects, oxidative stress, etc.) explained by shift expression toward more rigid N2B isoform, hypophosphorylation kinases A G or dephosphorylation serine / threonine phosphatase 5 molecule extensible segment containing unique sequence, hyperphosphorylation PEVK regions kinase C, as well inhibition Ca 2 +-dependent – actin interaction. results deciphering these become tool for developing new approaches targeted therapy currently does not have treatment, on one hand, key therapeutic effects drugs already used treat chronic with preserved ejection fraction, other hand.

Language: Английский

Citations

1