NK Cell‐Based Cancer Immunotherapies: Current Progress, Challenges and Emerging Opportunities DOI
Mohammad Y. Alshahrani, Subasini Uthirapathy, Abhinav Kumar

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Nov. 1, 2024

Natural killer (NK) cells are vital innate immune that play a crucial role in cancer therapy. They targeted by therapies designed to modulate, retain, and enhance their antitumor function vivo. In addition whole-cell therapy, NK cell-derived exosomes (NDEs) offer high safety easily subject chemical, biological, immunological modifications. This makes them suitable for use combination with various current efficacy, treatment outcomes, reduce side effects review aims outline summarizes the potential of cells, as well challenges opportunities cell-based immunotherapies such allogeneic autologous cell transplantation, CAR cytokines monoclonal antibodies. The also explores dual regulatory tumor on highlights NDEs, either alone or other therapies, reprogram immunosuppressive microenvironment expedite therapeutic immunotherapy future clinical research.

Language: Английский

CAR T Cells in Lung Cancer: Targeting Tumor-Associated Antigens to Revolutionize Immunotherapy DOI
Sattam Khulaif Alenezi

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155947 - 155947

Published: March 1, 2025

Language: Английский

Citations

1
Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Citations

1
In Vitro models of leukemia development: the role of very small leukemic stem-like cells in the cellular transformation cascade DOI Creative Commons
Jan Jakub Lica, Joanna Jakóbkiewicz‐Banecka,

Andrzej Hellmann

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

Recent experimental findings indicate that cancer stem cells originate from transformed very small embryonic-like cells. This finding represents an essential advancement in uncovering the processes drive onset and progression of cancer. In continuously growing cell lines, for first time, our team's follow-up research on leukemia, lung cancer, healthy embryonic kidney revealed stages resembles precursor review explores origin leukemic stem-like establish We explore theoretical model acute myeloid leukemia initiation progresses through various stages, as well basing HL60 line, present its hierarchical stage development vitro, highlighting role these primitive stages. also discuss potential implications further into unique cellular advancing treatment prevention.

Language: Английский

Citations

0
Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis DOI Creative Commons
Yanfei Jia, Luoming Zhang, Wei Zhou

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Breast cancer remains the most prevalent malignancy and leading cause of cancer-related mortality among women worldwide. The primary factors contributing to deterioration death patients with breast are metastasis, recurrence, drug resistance. These phenomena closely related presence stem cells; however, exact mechanisms regulating stemness remain be elucidated. Rack1 (Receptor for Activated C Kinase 1), a well-known versatile scaffold protein, has been implicated in tumorigenesis progression numerous types; its specific role Using bioinformatic immunohistochemical approaches, we validated that expression level is associated affects prognosis patients. Through series experimental methods including mammosphere formation assay, flow cytometry, qPCR, Western blotting, CHX assays, at molecular cellular levels mechanism by which influences via E2F1/SOX2 axis. Furthermore, designing utilizing lentiviral constructs establish xenograft tumor models mice, further confirmed vivo impact Rack1/E2F1/SOX2 axis on tumorigenic capacity cells. Our findings indicate plays critical preserving characteristics Mechanistically, observed effects achieved through modulation SOX2 expression, master transcription factor regulates cell maintenance. We demonstrate increases stability E2F1 protein inhibiting ubiquitination subsequent proteasome-mediated degradation, turn transcriptionally upregulates SOX2, thereby maintaining tumorigenesis. This study thus unveils novel executes oncogenic function. also demonstrates targeting Rack1-E2F-SOX2 may potential strategy inhibit development progression.

Language: Английский

Citations

0
Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations DOI Creative Commons

Joseph Nhyira Obisi,

Abike Ndidiamaka Josephine Abimbola,

Oluwasegun Adesina Babaleye

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

Citations

0
NK Cell‐Based Cancer Immunotherapies: Current Progress, Challenges and Emerging Opportunities DOI
Mohammad Y. Alshahrani, Subasini Uthirapathy, Abhinav Kumar

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Nov. 1, 2024

Natural killer (NK) cells are vital innate immune that play a crucial role in cancer therapy. They targeted by therapies designed to modulate, retain, and enhance their antitumor function vivo. In addition whole-cell therapy, NK cell-derived exosomes (NDEs) offer high safety easily subject chemical, biological, immunological modifications. This makes them suitable for use combination with various current efficacy, treatment outcomes, reduce side effects review aims outline summarizes the potential of cells, as well challenges opportunities cell-based immunotherapies such allogeneic autologous cell transplantation, CAR cytokines monoclonal antibodies. The also explores dual regulatory tumor on highlights NDEs, either alone or other therapies, reprogram immunosuppressive microenvironment expedite therapeutic immunotherapy future clinical research.

Language: Английский

Citations

2