Neoplasia, Journal Year: 2024, Volume and Issue: 58, P. 101072 - 101072
Published: Oct. 24, 2024
Language: Английский
Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9
Published: Jan. 7, 2025
Background The hemoglobin, albumin, lymphocyte, and platelet (HALP) score could be a prognostic biomarker in patients with cancer as reflector of nutritional inflammatory status, although the data is limited treated immune-checkpoint inhibitors (ICIs). Therefore, we sought to investigate relationship between HALP survival ICI-treated patients.
Language: Английский
Citations
1
Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14
Published: May 31, 2024
In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells, progenitor exhausted (Tpex) has been identified. These Tpex cells are notable for their remarkable self-renewal rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that expand differentiate into responsive thus underscoring critical role the immunotherapeutic retort. Clinical examinations further clarified robust positive correlation between proportional abundance enhanced clinical prognosis. found noteworthy applications formulation inventive approaches against tumors. This review describes functions tumor milieu, particularly potential utility immunotherapy. Precisely directing may be essential to achieving successful outcomes
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
Age-associated defects in T cell-mediated immunity can increase the risk of cancers, but how aging influences adoptive T-cell therapy (ACT) for cancers remains unclear. Here, using a mouse model melanoma, we demonstrate that diminishes anti-tumor activity engineered CD8 cells expressing tumor-specific cell receptor (CD8 TCR-T cells) ACT solid tumors. Aged cannot control tumor growth either young or aged mice. are unable to accumulate efficiently tumors and have higher tendency become terminally exhausted with lower expression endothelial PAS domain-containing protein 1 (Epas1) compared cells. Crispr-mediated ablation Epas1 promotes terminal exhaustion tumors, diminishing their Conversely, retroviral enhances These findings suggest aging-induced reduction impairs against which be therapeutically improved by exogenous Epas1.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 11, 2025
Tumor-draining lymph nodes (TDLNs) play a crucial role in modulating tumor immune responses and influencing the efficacy of immunotherapy. However, our current understanding microenvironment within these remains limited. Tumors not only impair anti-tumor activity CD8 + T cells by creating an immunosuppressive microenvironment, but they also facilitate evasion promote metastasis altering structure function TDLNs. Research has shown that tumor-specific memory (T TSM ) TDLNs are essential for checkpoint inhibitors, such as PD-1/PD-L1 blockers. Moreover, abnormal TDLNs, along with presence cells—such regulatory (Tregs), B (Bregs), dendritic (DCs)—contributes to tumor-mediated evasion. Therefore, gaining deeper is improving effectiveness immunotherapies developing novel therapeutic strategies. This review explores various TDLN-based strategies, addressing controversies surrounding node dissection, use source tumor-infiltrating lymphocytes (TILs) therapy, targeting methods reverse structural abnormalities These strategies offer valuable insights potential directions advancing
Language: Английский
Citations
0
Neoplasia, Journal Year: 2024, Volume and Issue: 58, P. 101072 - 101072
Published: Oct. 24, 2024
Language: Английский
Citations
3