Published: May 10, 2024
Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of post-mitotic cells with age. Drs. Brunk Terman postulated lipofuscin accumulation main or at least a major driving factor aging. They even posited evolution memory reason why we get all, as stable synaptic connections must be maintained over time, meaning somas neurons also remain same locale. In other words, they cannot dilute out their time through cell division. Mechanistically, position certainly makes sense given rendering large percentage cell’s lysosomes useless almost negatively affect surrounding microenvironment. It may case issue regard to current age-related disease. Degradation situ an insurmountable task currently. However, method systemic removal discussed herein.
Language: Английский