S protein, ACE2 and Host Cell Proteases in SARS-CoV2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? DOI Open Access
Reza Nejat,

Maziar Fayaz Torshizi,

David J. Najafi

et al.

Published: Dec. 2, 2022

Since the spread of deadly virus SARS-CoV2 in late 2019, researchers have restlessly been seeking for unraveling how factually enters host cells. Some proteins on each side interaction between and cells are involved as major contributors to this process: 1- nano-machine Spike protein behalf virus, 2- angiotensin converting enzyme II, mono-carboxypeptidase key component renin system cell, 3- some proteases exploited by SARS-CoV2, In review, complex process entrance into with contribution well sequential conformational changes tending increase probability complexification latter receptor cells, discussed. Besides, release catalytic ectodomain II its soluble form extracellular space positive or negative impact infectivity considered.

Language: Английский

S protein, ACE2 and Host Cell Proteases in SARS-CoV2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? DOI Open Access
Reza Nejat,

Maziar Fayaz Torshizi,

David J. Najafi

et al.

Published: Dec. 2, 2022

Since the spread of deadly virus SARS-CoV2 in late 2019, researchers have restlessly been seeking for unraveling how factually enters host cells. Some proteins on each side interaction between and cells are involved as major contributors to this process: 1- nano-machine Spike protein behalf virus, 2- angiotensin converting enzyme II, mono-carboxypeptidase key component renin system cell, 3- some proteases exploited by SARS-CoV2, In review, complex process entrance into with contribution well sequential conformational changes tending increase probability complexification latter receptor cells, discussed. Besides, release catalytic ectodomain II its soluble form extracellular space positive or negative impact infectivity considered.

Language: Английский

Citations

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