Endogenous piRNAs Can Interact with Omicron Variant of the SARS-CoV-2 Genome DOI Open Access
Aizhan Rakhmetullina, Aigul Akimniyazova,

Togzhan Niyazova

et al.

Published: Feb. 7, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic still able to infect population in many countries. The Omicron strain is most mutated variant of SARS-CoV-2. high transmissibility and ability evade immunity require a priority study its properties order quickly create effective means preventing it. present work devoted silico interaction piRNAs with genome SARS-CoV-2 (gRNA) identify endogenous propose synthetic antiviral activity for drug development. studies were carried out using proven bioinformatic methods entire more than eight million piRNAs. Binding sites (BSs) 5'UTR located overlapping nucleotide sequences called clusters BSs. Several BSs found nsp3, nsp7, RNA-dependent RNA polymerase, endoRNAse, S surface glycoprotein, ORF7a nucleocapsid. 16 have been proposed interact gRNA free binding energy from -170 kJ/mol -175 kJ/mol, which can be used drugs suppress reproduction

Language: Английский

Endogenous piRNAs Can Interact with Omicron Variant of the SARS-CoV-2 Genome DOI Open Access
Aizhan Rakhmetullina, Aigul Akimniyazova,

Togzhan Niyazova

et al.

Published: Feb. 7, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic still able to infect population in many countries. The Omicron strain is most mutated variant of SARS-CoV-2. high transmissibility and ability evade immunity require a priority study its properties order quickly create effective means preventing it. present work devoted silico interaction piRNAs with genome SARS-CoV-2 (gRNA) identify endogenous propose synthetic antiviral activity for drug development. studies were carried out using proven bioinformatic methods entire more than eight million piRNAs. Binding sites (BSs) 5'UTR located overlapping nucleotide sequences called clusters BSs. Several BSs found nsp3, nsp7, RNA-dependent RNA polymerase, endoRNAse, S surface glycoprotein, ORF7a nucleocapsid. 16 have been proposed interact gRNA free binding energy from -170 kJ/mol -175 kJ/mol, which can be used drugs suppress reproduction

Language: Английский

Citations

1