Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1774 - 1774

Published: March 20, 2024

Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms signs. Women PCOS are at increased risk pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, pre-eclampsia (PE). This may be attributed to the presence specific susceptibility features associated before during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), hyperandrogenism, all which have been an complications. Many reversible following lifestyle interventions diet exercise, pregnant women healthy found lower complications, PE. narrative synthesis summarizes evidence investigating PE role nutritional factors in PCOS. The findings suggest beneficial aspects management PCOS, recommended evidence-based international guidelines, extend improved outcomes. Identifying high-risk will allow targeted interventions, early-pregnancy screening, surveillance for should included assessment algorithms

Language: Английский

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Macronutrients and Disease: Polycystic Ovary Syndrome

Published: Jan. 1, 2025

Language: Английский

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Special Issue “New Challenges and Perspectives in Polycystic Ovary Syndrome”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2665 - 2665

Published: March 15, 2025

Polycystic ovary syndrome (PCOS) is a complex multisystem metabolic and endocrine disorder that impacts health throughout the lifespan [...]

Language: Английский

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The Impact of Feeding Rates on the Growth, Stress Response, Antioxidant Capacity, and Immune Defense of Koi (Cyprinus carpio var. koi)

Fishes, Journal Year: 2025, Volume and Issue: 10(4), P. 181 - 181

Published: April 16, 2025

The feeding rate is critical for fish growth and the feed conversion ratio (FCR). Prior research has primarily evaluated optimal by examining performance FCR. Given high cost of koi as an ornamental fish, it essential to consider effects rates on its welfare health. This study aimed examine impact growth, stress response, antioxidant capacity, immune defense koi. A total 240 with initial body weight 10.02 ± 0.18 g, were randomly assigned six groups fed expanded diets at 1%, 2%, 3%, 4%, 5%, 6% per day (BW/day) a duration eight weeks. results indicated that daily gain 3–4% BW/day was significantly greater than other groups. Fish in both low exhibited reduced capacity heightened inflammatory notable decrease catalase (CAT) superoxide dismutase (SOD) activity, along diminished expression cat sod, well significant increase tnf-α, il1, il10. elevated did not enhance mechanisms. Furthermore, resulted immunity koi, reduction plasma cortisol (COR), complement C3, C4, protein (TP), albumin (ALB), globulin (GLO) levels, decreased activities lysozyme (LZM) myeloperoxidase (MPO). enhancing non-specific intake extruded feed. Our findings reveal underfeeding led antioxidants defenses while overfeeding also proved detrimental. An necessary health this species.

Language: Английский

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An Evolutionary Model for the Ancient Origins of Polycystic Ovary Syndrome

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(19), P. 6120 - 6120

Published: Sept. 22, 2023

Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged women, characterized by hyperandrogenism, oligo-anovulation and insulin resistance closely linked with preferential abdominal fat accumulation. As an ancestral primate trait, PCOS was likely further selected in humans when scarcity food hunter–gatherers the late Pleistocene additionally programmed for enhanced storage to meet metabolic demands reproduction later life. evolutionary model PCOS, healthy normal-weight women hyperandrogenic have subcutaneous (SC) adipose stem cells that favor through exaggerated lipid accumulation during development adipocytes vitro. In turn, counterbalanced reduced sensitivity highly lipolytic intra-abdominal vivo. This adaptation balances energy glucose availability fatty acid oxidation optimal use reproduction; its accompanying allowed from antiquity sufficient time strength childrearing fewer offspring greater likelihood childhood survival. Heritable characteristics are affected today’s contemporary environment epigenetic events predispose lipotoxicity, excess weight gain pregnancy complications, calling emphasis on preventive healthcare optimize long-term, endocrine-metabolic health obesogenic environment.

Language: Английский

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Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms that Disturb the Hallmarks of Health in Polycystic Ovary Syndrome

Published: March 30, 2023

Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary mismatch disorder that presents with a complex mixture of metabolic and endocrine symptoms. The Evolutionary Model proposes PCOS arises from collection inherited polymorphisms have been consistently demonstrated in variety ethnic groups races. In-utero developmental programming susceptible genomic variants are thought to predispose the offspring develop PCOS. Postnatal exposure lifestyle environmental risk factors results epigenetic activation developmentally programmed genes disturbance hallmarks health. resulting pathophysiological changes represent consequences poor-quality diet, sedentary behaviour, disrupting chemicals, stress, circadian disruption, other factors. Emerging evidence suggests lifestyle-induced gastrointestinal dysbiosis plays central role pathogenesis Lifestyle exposures initiate result microbiome (dysbiosis), immune dysregulation (chronic inflammation), altered metabolism (insulin resistance), reproductive imbalance (hyperandrogenism), nervous system dysfunction (neuroendocrine, autonomic system). can be progressive condition leads obesity, gestational diabetes, type 2 metabolic-associated fatty liver disease, syndrome, cardiovascular cancer. This review explores mechanisms underpin between ancient survival pathways contemporary involved pathophysiology

Language: Английский

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