Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19 DOI Open Access
Zoia R. Korobova, N. A. Аrsentieva, Арег А. Тотолян

et al.

Published: May 6, 2023

Macrophage-derived chemokine belongs to the CC subfamily. It is produced by dendritic cells (DCs) and macrophages with or without external stimulation. We have previously shown a statistically significant depletion of MDC/CCL22 concentrations in number studies concerning COVID-19. These shifts demonstrated stability unrelated SARS-CoV-2 genetic variant remained noticeable even convalescent patients. In this work, we analyze dynamics various diseases, including those that manifest inflammation lung tissue. addition, provide our hypothesis on such decrease If its secretion producer unperturbed, then it possible for viral products bind block functional activity. There is, however, another explanation directly linked DC subpopulations inhibition their function. also discuss MDC/CCL22's role immunology novel coronavirus infection, based both own data other studies.

Language: Английский

Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19 DOI Open Access
Zoia R. Korobova, N. A. Аrsentieva, Арег А. Тотолян

et al.

Published: May 6, 2023

Macrophage-derived chemokine belongs to the CC subfamily. It is produced by dendritic cells (DCs) and macrophages with or without external stimulation. We have previously shown a statistically significant depletion of MDC/CCL22 concentrations in number studies concerning COVID-19. These shifts demonstrated stability unrelated SARS-CoV-2 genetic variant remained noticeable even convalescent patients. In this work, we analyze dynamics various diseases, including those that manifest inflammation lung tissue. addition, provide our hypothesis on such decrease If its secretion producer unperturbed, then it possible for viral products bind block functional activity. There is, however, another explanation directly linked DC subpopulations inhibition their function. also discuss MDC/CCL22's role immunology novel coronavirus infection, based both own data other studies.

Language: Английский

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