Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 420 - 420

Published: March 21, 2024

Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential attributed to the significant presence polysaccharides, glycopeptides, polyphenols, flavonoids, carotenoids, their derivatives. These compounds effectively counteract action free radicals, positively influencing cellular balance intracellular signaling, contributing overall cell function acting on multiple molecular pathways. Several fractions extracted berries demonstrate antitumor properties, particularly effective against breast cancer, without cytotoxic normal human cells. Hence, review explored fundamental traits bioactive elements in barbarum cancer treatment and, specifically, cancer. It focused elucidating wolfberry’s influenced biochemical pathways, its synergism anticancer drugs, alleviate side existing treatments.

Language: Английский

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Anticancer Therapies Based on Oxidative Damage: Lycium barbarum Inhibits the Proliferation of MCF-7 Cells by Activating Pyroptosis through Endoplasmic Reticulum Stress

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 708 - 708

Published: June 11, 2024

Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also an important source of bioactive compounds such polysaccharides, carotenoids, phenolics, various other non-nutritive compounds. These constituents give it a multitude health benefits, including antioxidant, anti-inflammatory, anticancer properties. However, the precise biochemical mechanisms responsible effects remain unclear, comprehensive composition extracts often insufficiently explored. This study aimed to investigate pathways modulated in breast cancer cells by ethanolic extract barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed antitumoral LBE on different cell lines. investigation revealed that exhibited cytotoxic effects, inducing pro-oxidant effect triggered pyroptosis activation through endoplasmic reticulum (ER) stress subsequent P-IRE1α/XBP1/NLRP3 axis MCF-7 cells. In addition, did display cytotoxicity toward healthy human demonstrated antioxidant neutralizing ROS generated doxorubicin. findings underscore potential promising natural therapy.

Language: Английский

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The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 1030 - 1030

Published: March 2, 2024

Hepatocellular carcinoma (HCC) is diagnosed annually in nearly a million people worldwide, with approximately half of them being at an advanced stage the disease. Non-infectious risk factors for development HCC include unbalanced lifestyle, including poor dietary choices characterized by low intake antioxidants, such as vitamins E and C, selenium, polyphenols, well excessive consumption energy harmful substances. Repeated bad that contribute to lifestyle lead accumulation fatty substances liver it entering inflammatory state, which, without intervention, results cirrhosis, main cause HCC. This review English language literature aims present food components that, when included daily diet, reduce developing HCC, identifying foods may have carcinogenic effect on cells.

Language: Английский

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Antiangiogenic Effects of Natural Compounds in Hepatic Inflammation

Published: May 18, 2023

Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty (NAFLD) are the most common causes of chronic liver disease increasingly emerging as a global health problem. Such disorders can lead to damage, resulting in release pro-inflammatory cytokines activation infiltrating immune cells. These some features ALD progression ASH (alcoholic steatohepatitis) NAFLD NASH (non-alcoholic steatohepa-titis). Hepatic steatosis subsequent fibrosis, whose continuous is accompanied by angiogenesis, hypoxia, inducing vascular factors, which turn triggers pathological angiogenesis vicious cycle. This condition further exacerbates injury may contribute development comorbidities, such metabolic syndrome well hepatocellular carcinoma. Increasing evidence suggests that antiangiogenic therapy have beneficial effects on these hepatic their exacerbation. Therefore, there great interest deepen knowledge molecular mechanisms natural products could both prevent control diseases. In this review, we focus role major antian-giogenic compounds against steatohepatitis determine potential therapeutic benefits treatment inflammation.

Language: Английский

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A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 53 - 53

Published: Jan. 5, 2025

Investigating amyloid-β (Aβ) peptides in solution is essential during the initial stages of developing lead compounds that can influence Aβ fibrillation while peptide still a soluble state. The tendency Aβ(1-42) to misfold solution, correlated aetiology Alzheimer's disease (AD), one main hindrances characterising its aggregation kinetics cell-mimetic environment. Moreover, triggers unfolded protein response (UPR) endoplasmic reticulum (ER), leading cellular dysfunction and multiple cell death modalities, exacerbated by reactive oxygen species (ROS), which damage components trigger inflammation. Antioxidants like curcumin, derivative Curcuma longa, help mitigate ER stress scavenging ROS enhancing antioxidant enzymes. Furthermore, evidence literature highlights effect curcumin on secondary structure Aβ(1-42). This explorative study investigates conformational behaviour presence six derivatives using circular dichroism (CD) explore their interactions with lipid bilayers, potentially preventing aggregate formation. results suggest synthetic tetrahydrocurcumin (THC) interacts amyloid all systems presented, cyclocurcumin (CYC) bisdemethoxycurcumin (BMDC) only interact when less stable conformation. Molecular dynamics simulations helped visualise curcuminoids' an aqueous system hypothesise importance surface exposition solvent, differently modulated derivatives.

Language: Английский

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Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of Rosmarinus officinalis L. Essential Oil from Southwestern Romania

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 681 - 681

Published: Jan. 11, 2025

Our study reports for the first time, over a 12-month period, seasonal variations in chemical composition and antibacterial antioxidant activity of Rosmarinus officinalis L. essential oil (RoEO) from Southwestern Romania (Oltenia region). To analyze constituents RoEO, comprehensive gas chromatography/mass spectrometry (GC/MS) method was employed. The analysis aimed to identify quantify various components by comparing their mass spectra with reference National Institute Standards Technology (NIST) Library 2020. minimum inhibitory concentration (MIC) values Staphylococcus aureus were determined using microdilution (96-well plates). analyzed 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), hydrogen peroxide (H2O2) radical scavenging assays. This provided detailed profile RoEO’s constituents, revealing significant monthly variations. Key compounds, such as camphor, eucalyptol, α-pinene, camphene, α-myrcene, quantified, alongside lesser-studied like β-pinene, α-terpinene, linalool, terpinolene, carvacrol. Comparisons made sample Tunisia. Oxygenated monoterpenes reach highest (56.82–66.94%), followed monoterpene hydrocarbons (30.06–40.28%), sesquiterpene (0.90–2.44%), oxygenated sesquiterpenes (0.02–0.23%). Camphor found high concentrations ranging 29.41% 40.03%. 1,8-Cineole another dominant compound, 13.07% 16.16%, significantly lower compared Tunisian (52.77%). α-Pinene ranged 11.36% 19.33%, while α-myrcene 1.65% 3.08%. Correlations between specific compounds bioactivity explored understand contributions overall efficacy RoEO. provides valuable insights into potential applications variability RoEO Romania.

Language: Английский

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Targeting the CXCR4/CXCL12 Axis in Cancer Therapy: Analysis of Recent Advances in the Development of Potential Anticancer Agents

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1380 - 1380

Published: March 20, 2025

Cancer, a leading cause of premature death, arises from genetic and epigenetic mutations that transform normal cells into tumor cells, enabling them to proliferate, evade cell stimulate angiogenesis. Recent evidence indicates chemokines are essential in development, activating receptors promote proliferation, invasion, metastasis. The CXCR4/CXCL12 signaling pathway is gaining attention as promising target for cancer therapy. CXCR4, chemokine receptor, often overexpressed various types cancer, including kidney, lung, brain, prostate, breast, pancreas, ovarian, melanomas. When it binds its endogenous ligand, CXCL12, promotes survival, migration, crucial mechanisms the retention hematopoietic stem bone marrow movement lymphocytes. extensive expression CXCR4 coupled with constant presence CXCL12 organs, drives activation this axis, which turn facilitates angiogenesis, progression, Given detrimental role search drugs acting selectively against protein represents an open challenge. This review aims summarize recent advancements design development antagonists potential anticancer agents.

Language: Английский

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Endoplasmic Reticulum Stress and Its Role in Metabolic Reprogramming of Cancer

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 221 - 221

Published: March 24, 2025

Background/Objectives: Endoplasmic reticulum (ER) stress occurs when ER homeostasis is disrupted, leading to the accumulation of misfolded or unfolded proteins. This condition activates protein response (UPR), which aims restore balance trigger cell death if cannot be achieved. In cancer, plays a key role due heightened metabolic demands tumor cells. review explores how metabolomics can provide insights into stress-related alterations and their implications for cancer therapy. Methods: A comprehensive literature was conducted analyze recent findings on stress, metabolomics, metabolism. Studies examining profiling cells under conditions were selected, with focus identifying potential biomarkers therapeutic targets. Results: Metabolomic studies highlight significant shifts in lipid metabolism, synthesis, oxidative management stress. These are crucial adaptation survival. Additionally, targeting pathways has shown preclinical models, suggesting new strategies. Conclusions: Understanding impact provides valuable opportunities drug development. Metabolomics-based approaches may help identify novel targets, enhancing effectiveness antitumor therapies.

Language: Английский

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Protective Effects of a Red Orange and Lemon Extract (RLE) on the Hepatotoxicity Induced by Ochratoxin A in Rats

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 289 - 289

Published: Feb. 27, 2024

Ochratoxin A (OTA) is a highly potent mycotoxin that contaminates many kinds of food and feed sources. Its significant impact on human health animal productivity makes it topic particular concern. The role specific bioactive compounds used as dietary antioxidants believed to be substantial due their capacity act free radical scavengers. Because the well-known oxidative stress induced by OTA, primary objective this work was evaluate antioxidant effects standardized powder extract recovered from citrus processing waste, red orange lemon (RLE), liver damage OTA in rat model. This study aimed examine oral administration RLE (90 mg/kg b.w.) hepatic function balance Sprague–Dawley rats (n = 6/group) treated with (0.5 over period 14 days. alone resulted both biochemical changes an imbalance redox status liver. However, use alleviated activity enzymes dramatically decreased serum levels ALT (alanine aminotransferase), AST (aspartate ALP (alkaline phosphatase), providing evidence its protective benefits. Based findings histology tests, mitigation lymphoplasmacytic inflammation, steatosis, necrosis group. These results indicate novel phytoextract holds potential for application field nutraceuticals.

Language: Английский

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Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1284 - 1284

Published: Oct. 24, 2024

The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with genesis/progression of several pathological conditions, including cancer, inflammation, neurodegenerative disorders, that directly indirectly correlated to a wide set events collectively named under term "ER stress". Despite recent increase interest concerning ER activity, further research studies needed highlight all mechanisms responsible for failure. In this field, discoveries paved way comprehension strong interaction between stress development endocannabinoid system. activity system mediated by activation cannabinoid receptors (CB), G protein-coupled induce decrease cAMP levels, downstream anti-inflammatory effects. CB drives, most cases, recovery through regulation hallmarks PERK, ATF6, IRE1. review, we focus on role modulating stress, particular attention processes leading UPR oxidative response extinguishment, underlying natural cannabinoids' modulation complex machine.

Language: Английский

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