Unveiling the Potentials of Withania somnifera (L.) Dunal as a Precise Therapeutic Intervention Against Glioblastoma Multiforme DOI Creative Commons
Sohini Kulavi,

Debajit Dhar,

Karan Iyer

et al.

Published: March 20, 2024

Glioblastoma multiforme (GBM) is the most severe and fatal form of brain tumor, leading to a poor survival rate in patients making significant contribution cancer-related deaths. The typical approaches treating GBM involve surgical procedures followed by chemotherapy, targeting molecular pathways involving receptors like Epidermal Growth Factor Receptor (EGFR, EGFRvIII) Vascular Endothelial (VEGFR) modulate various cell signaling pathways. However, effectiveness current treatments notably constrained. Withania somnifera (WS) (L.) Dunal, commonly known as Ashwagandha, has history spanning over 3,000 years Ayurvedic traditional medicine. This medicinal plant diverse properties, encompassing anti-inflammatory, anticancer antioxidant attributes. Recent advancements field herbal medicines have explored its potential managing deadly diseases cancer. Ashwagandha or W. somnifera, mostly found dry, sub-tropical regions world including India, well-known source medicines, many specific phytochemicals, viz. Withaferin A, Withanolide etc. review discusses supported several research reports dealing with extracts phytochemicals from different parts plant, showing against

Language: Английский

Exploring Silybin B as a FOXM1 Inhibitor in Glioblastoma Stem Cells: Molecular Docking, ADMET, and Molecular Dynamics Approaches DOI Open Access
Swati Kumari, Sameer Quazi, Rashi Srivastava

et al.

Published: June 28, 2023

Glioblastoma multiforme (GBM) is a highly heterogeneous brain tumor with limited treatment options and poor prognosis. Cancer stem cells (CSCs) have emerged as critical factor in GBM resistance management, contributing to growth, heterogeneity, immunosuppression. The transcription FOXM1 has been identified key player the progression, spread, therapy of various cancers, including GBM. In this study, researchers conducted structure-based silico screening identify natural compounds that could target DNA-binding domain (DBD) protein. Through molecular docking analyses, Silybin B potential inhibitor FOXM1, exhibiting strong interaction MD simulations were performed validate binding stability FOXM1-Silybin complex. study provides valuable insights into its ability induce senescence cells. These findings contribute development design strategies for inhibitors innovative therapeutic approaches Glioblastoma.

Language: Английский

Citations

2
Unveiling the Potentials of Withania somnifera (L.) Dunal as a Precise Therapeutic Intervention Against Glioblastoma Multiforme DOI Creative Commons
Sohini Kulavi,

Debajit Dhar,

Karan Iyer

et al.

Published: March 20, 2024

Glioblastoma multiforme (GBM) is the most severe and fatal form of brain tumor, leading to a poor survival rate in patients making significant contribution cancer-related deaths. The typical approaches treating GBM involve surgical procedures followed by chemotherapy, targeting molecular pathways involving receptors like Epidermal Growth Factor Receptor (EGFR, EGFRvIII) Vascular Endothelial (VEGFR) modulate various cell signaling pathways. However, effectiveness current treatments notably constrained. Withania somnifera (WS) (L.) Dunal, commonly known as Ashwagandha, has history spanning over 3,000 years Ayurvedic traditional medicine. This medicinal plant diverse properties, encompassing anti-inflammatory, anticancer antioxidant attributes. Recent advancements field herbal medicines have explored its potential managing deadly diseases cancer. Ashwagandha or W. somnifera, mostly found dry, sub-tropical regions world including India, well-known source medicines, many specific phytochemicals, viz. Withaferin A, Withanolide etc. review discusses supported several research reports dealing with extracts phytochemicals from different parts plant, showing against

Language: Английский

Citations

0