Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the Therapeutics DOI Open Access

Naoko Suga,

Yuka Ikeda, Sayuri Yoshikawa

et al.

Published: June 29, 2023

Changes in epitranscriptome with N6‐methyladenine (m6A) modification could be involved the development of multiple diseases, which might a prevalent messenger RNAs (mRNAs) eukaryotes. The m6A performed through action methyltransferases, demethylases, and methylation-binding proteins. Importantly, methylation may associated various neurological disorders including Alzheimer's disease (AD), Parkinson's (PD), depression, aging related and/or itself. In addition, functionally regulate eukaryotic transcriptome by influencing splicing, export, subcellular localization, translation, stability, decay mRNAs. Neurodegenerative diseases possess wide variety phenotypes depending on neurons that degenerate at occasions. Interestingly, increasing number evidences have indicated modulate expression autophagy-related genes promote autophagy neuronal cells. Oxidative stresses such as reactive oxygen species (ROS) stimulate RNA methylation, also to regulation neurodegenerative diseases. Both play critical roles regulating health condition neurons. Therefore, comprehensive understanding relationship human benefit developing therapeutic strategies future. This paper reviews advances regulatory mechanisms occurrence aging, discussing possible procedures autophagy.

Language: Английский

Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the Therapeutics DOI Open Access

Naoko Suga,

Yuka Ikeda, Sayuri Yoshikawa

et al.

Published: June 29, 2023

Changes in epitranscriptome with N6‐methyladenine (m6A) modification could be involved the development of multiple diseases, which might a prevalent messenger RNAs (mRNAs) eukaryotes. The m6A performed through action methyltransferases, demethylases, and methylation-binding proteins. Importantly, methylation may associated various neurological disorders including Alzheimer's disease (AD), Parkinson's (PD), depression, aging related and/or itself. In addition, functionally regulate eukaryotic transcriptome by influencing splicing, export, subcellular localization, translation, stability, decay mRNAs. Neurodegenerative diseases possess wide variety phenotypes depending on neurons that degenerate at occasions. Interestingly, increasing number evidences have indicated modulate expression autophagy-related genes promote autophagy neuronal cells. Oxidative stresses such as reactive oxygen species (ROS) stimulate RNA methylation, also to regulation neurodegenerative diseases. Both play critical roles regulating health condition neurons. Therefore, comprehensive understanding relationship human benefit developing therapeutic strategies future. This paper reviews advances regulatory mechanisms occurrence aging, discussing possible procedures autophagy.

Language: Английский

Citations

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