Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection DOI Creative Commons
Leonardo Albarracín, Stefanía Dentice Maidana,

Kohtaro Fukuyama

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1600 - 1600

Published: Dec. 14, 2024

Orally administered immunomodulatory lactobacilli can stimulate respiratory immunity and enhance the resistance to primary infections with bacterial viral pathogens. However, potential beneficial effects of against superinfection have not been evaluated. In this work, we showed that feeding infant mice Lacticaseibacillus rhamnosus CRL1505 or Lactiplantibacillus plantarum MPL16 strains reduce susceptibility secondary pneumococcal infection produced after activation TLR3 in tract RVS. The treatment by oral route improved production interferons tract, differentially modulated balance pro- anti-inflammatory cytokines, reduced replication, diminished lung damage. Additionally, demonstrated orally confer longstanding protection Streptococcus pneumoniae effect would be mediated stimulation trained alveolar macrophages. This work contributes revealing mechanisms involved modulation gut–lung axis microbes demonstrating specific strains, through common mucosal immune system, able support development macrophages challenges a inflammatory event mucosa.

Language: Английский

Immune Resilience to SARS-CoV-2 Infection by Shifting Risk Within Normal and Disease Populations DOI Open Access

Robert Clancy

Published: July 5, 2023

ABSTRACT: The idea of a Common Mucosal Immune system (CMS) is 50 years old. Its relevance to immune protection at mucosal sites and its potential modulate the impact vaccination-induced against infection airway, has been poorly understood. consequent failure current SARS-CoV-2 vaccination satisfy expectations with respect prevention infection, viral transmission, duration pattern clinical protection, led public health medical decisions now under review. This review summarises knowledge CMS in man, including powerful role it plays lessons what can not be achieved by systemic for airway infection. both disease optimising delivery using selected isolates from respiratory microbiome, demonstrated through randomised controlled trials (RCT’s) subjects chronic disease, otherwise healthy individuals risk factors, whom resilience introduced.

Language: Английский

Citations

2
Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection DOI Creative Commons
Leonardo Albarracín, Stefanía Dentice Maidana,

Kohtaro Fukuyama

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1600 - 1600

Published: Dec. 14, 2024

Orally administered immunomodulatory lactobacilli can stimulate respiratory immunity and enhance the resistance to primary infections with bacterial viral pathogens. However, potential beneficial effects of against superinfection have not been evaluated. In this work, we showed that feeding infant mice Lacticaseibacillus rhamnosus CRL1505 or Lactiplantibacillus plantarum MPL16 strains reduce susceptibility secondary pneumococcal infection produced after activation TLR3 in tract RVS. The treatment by oral route improved production interferons tract, differentially modulated balance pro- anti-inflammatory cytokines, reduced replication, diminished lung damage. Additionally, demonstrated orally confer longstanding protection Streptococcus pneumoniae effect would be mediated stimulation trained alveolar macrophages. This work contributes revealing mechanisms involved modulation gut–lung axis microbes demonstrating specific strains, through common mucosal immune system, able support development macrophages challenges a inflammatory event mucosa.

Language: Английский

Citations

0