An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome
Shuaiming Jiang,
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Wenyao Ma,
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Chenchen Ma
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et al.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 8, 2024
The
occurrence
and
progression
of
tumors
are
often
accompanied
by
disruptions
in
the
gut
microbiota.
Inversely,
impact
microbiota
on
initiation
cancer
is
becoming
increasingly
evident,
influencing
tumor
microenvironment
(TME)
for
both
local
distant
tumors.
Moreover,
it
even
suggested
to
play
a
significant
role
process
immunotherapy,
contributing
high
specificity
therapeutic
outcomes
long-term
effectiveness
across
various
types.
Probiotics,
with
their
generally
positive
influence
microbiota,
may
serve
as
effective
agents
synergizing
immunotherapy.
They
crucial
activating
immune
system
inhibit
growth.
In
summary,
this
comprehensive
review
aims
provide
valuable
insights
into
dynamic
interactions
between
probiotics,
cancer.
Furthermore,
we
highlight
recent
advances
mechanisms
using
probiotics
improve
By
understanding
these
complex
relationships,
unlock
innovative
approaches
diagnosis
treatment
while
optimizing
effects
Language: Английский
Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice
Published: July 10, 2023
Probiotics
are
now
being
looked
at
as
a
possible
addition
to
cancer
treatments
in
both
study
and
clinical
settings.
This
tries
give
an
overview
of
probiotic
research
it
relates
cancer,
with
focus
on
how
might
help
avoid
treat
it,
improve
the
health
patients.
We
look
developmental
studies
that
use
cell
culture
animal
models
well
probiotics
work
cancer.
change
immune
system,
inflammation,
gut
bacteria.
The
results
add-on
therapy
for
patients
see
they
affected
treatment
success,
side
effects,
quality
life
benefits
certain
types
such
colorectal
breast
stomach
tumors.
also
find
best
strains
each
type
synergistic
combining
standard
like
chemotherapy,
radiation
therapy,
immunotherapy
effectiveness
lower
effects.
Lastly,
we
talk
about
present
problems
future
directions
personalized
methods,
ideal
doses
plans,
finding
signs
making
probiotic-based
therapies.
By
learning
more
could
be
used
can
create
personalized,
successful,
well-tolerated
outcomes.
Language: Английский