Role of Bruton's Tyrosine Kinase (BTK) in the Treatment of Cognitive Impairment in Patients with Multiple Sclerosis DOI Open Access
Elnaz Asadollahzadeh, Zahra Ebadi, Nasim Rezaeimanesh

et al.

Published: July 14, 2023

Multiple sclerosis (MS) is a persistent inflammatory disease affecting the central nervous system. Bruton's tyrosine kinase (BTK) an enzyme crucial in communication process of B cells, which have significant impact on development MS. Recently, BTK inhibitors emerged as promising treatment strategy for MS due to their ability modulate immune In this study, extensive literature search was performed utilizing multiple databases, such PubMed, Embase, and Scopus examine potential use managing cognitive disorders experienced by individuals with We found that targeting microglia offer advantages neurodegeneration associated impairments patients slowing down degeneration processes effectively. Their microglial function penetrate CNS positions them candidates improving function. This study suggests provide new possibilities neurodegenerative phases through effects activation pathways. Further research clinical trials are necessary fully explore efficacy treating while addressing barriers related impairment.

Language: Английский

Role of Bruton's Tyrosine Kinase (BTK) in the Treatment of Cognitive Impairment in Patients with Multiple Sclerosis DOI Open Access
Elnaz Asadollahzadeh, Zahra Ebadi, Nasim Rezaeimanesh

et al.

Published: July 14, 2023

Multiple sclerosis (MS) is a persistent inflammatory disease affecting the central nervous system. Bruton's tyrosine kinase (BTK) an enzyme crucial in communication process of B cells, which have significant impact on development MS. Recently, BTK inhibitors emerged as promising treatment strategy for MS due to their ability modulate immune In this study, extensive literature search was performed utilizing multiple databases, such PubMed, Embase, and Scopus examine potential use managing cognitive disorders experienced by individuals with We found that targeting microglia offer advantages neurodegeneration associated impairments patients slowing down degeneration processes effectively. Their microglial function penetrate CNS positions them candidates improving function. This study suggests provide new possibilities neurodegenerative phases through effects activation pathways. Further research clinical trials are necessary fully explore efficacy treating while addressing barriers related impairment.

Language: Английский

Citations

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