Soft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia

Journal of Osteopathic Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Context Sarcopenia is a disease characterized by low muscle mass and function that places individuals at greater risk of disability, loss independence, death. Current therapies include addressing underlying performance issues, resistance training, and/or nutritional strategies. However, these approaches have significant limitations, chronic inflammation associated with sarcopenia may blunt the anabolic response to exercise nutrition. This presents an unmet need for treatment strategies promote gains in function. One such possibility soft tissue manipulation (STM), which noninvasive, nonpharmacological mechanotherapy employed osteopathic physicians, physiotherapists, massage therapists, wherein tissues are subjected mechanical forces delivered hand or instrument. molecular effects STM remain largely unknown. Objectives In present study, we utilized rat model due disuse atrophy examined on recovery regulation pro-/anti-inflammatory cytokines. Methods Ten-week-old male Brown Norway rats were 2-week hindlimb suspension (HLS) then allowed re-ambulate 8 days without instrument-assisted (IASTM) applied right hindlimb. Muscle weights determined treated nontreated hindlimbs, membrane-based cytokine arrays performed serum. Results Following suspension, IASTM enhanced effectiveness re-ambulation (Re-A) both contralateral limbs. was changes numerous cytokines skeletal sera. Several factors observe be regulated also shown other studies, including ciliary neurotrophic factor (CNTF), IL-1β, IL-2, IL-3, IL-13, ICAM-1, tumor necrosis alpha (TNF-α), whereas others reported first time. Conclusions Our study adds further support role manual therapy musculoskeletal health details molecular-level target circulation. hold promise recovering related conditions as age-related sarcopenia.

Language: Английский

Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain

Published: July 25, 2023

Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves medication, but there need for non-pharmacological non-invasive interventions. Soft tissue manipulation (STM) such as massage has been shown to be effective in human subjects, the molecular mechanisms underlying these findings are not well understood. In this paper, we evaluated potential changes soft levels of more than thirty pro- or anti-inflammatory cytokines following instrument-assisted STM (IASTM) rats with chronic, induced LBP using Complete Freund’s Adjuvant. Our results indicate IASTM associated reduced RANTES/CCL5 increased IL-4, which pro-inflammatory factors, respectively, by 120 minutes post-treatment. was tissue-level CXCL5/LIX (the murine homologue IL-8), CXCL7, GM-CSF ICAM-1, IL1-ra, IL-6, IP-10/CXCL10, L-selectin, TNF-α, VEGF at either 30- Combined, our suggest exerts effects improved clinical outcomes potentially beneficial pro/anti-inflammatory circulation level.

Language: Английский