Evaluation of Adipokine Status and Leptin Receptor Gene Polymorphism in Patients with Severe Asthma
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(9), P. 1154 - 1154
Published: May 1, 2025
Background:
Severe
and
difficult-to-control
asthma
occurs
in
3-10%
of
patients
developed
countries.
The
aim
our
study
was
to
investigate
the
association
prognostic
role
leptin
adiponectin,
as
well
receptor
gene
polymorphism
Gln223Arg,
with
severe
asthma.
Methods:
present
included
200
hospitalized
Department
Pulmonology
between
January
2018
December
2021.
In
all
patients,
addition
routine
clinical
investigations,
their
ratio
were
analyzed,
levels
pro-inflammatory
cytokines
(IL-6,
IL-8
TNF-alpha).
External
respiratory
function
also
assessed.
LEPR
Gln223Arg
single-nucleotide
polymorphisms
genotyped
by
real-time
PCR
method.
Results:
Patients
randomized
into
two
groups,
depending
on
severity
asthma:
an
uncontrolled
group
a
controlled
group,
according
GINA
criteria.
Among
asthma,
101
subjects
(74.3%)
had
metabolic
syndrome
(p
<
0.001).
There
inverse
adiponectin/leptin
eosinophil
count
(B
=
-0.305,
p
0.001),
IL-6
-0.026,
-0.062,
0.001)
TNF-alpha
-0.047,
direct
correlation
level
FEV1
0.121,
FVC
0.104,
A
probable
homozygous
A/A
allele
increased
risk
shown
0.007).
Conclusions:
Leptin
genotype
may
be
associated
higher
probability
developing
Language: Английский
Asthma Phenotypes in the Era of Personalized Medicine
Published: July 24, 2023
Asthma
is
a
prevalent
disease
that
around
300
million
worldwide,
resulting
in
substantial
morbidity,
mortality,
and
economic
burden
on
global
scale.
New
clinical
laboratory
research
has
shed
light
the
immunology
causing
asthma.
now
recognized
as
heterogeneous
disease.
A
personalized
medicine
based
classification
of
asthma
by
endotype
linking
observable
characteristics
to
immunological
mechanisms.
Identifying
mechanisms
essential
for
better
characterizing
patients
personalizing
therapeutic
approaches
with
novel
biological
agents
target
specific
immune
pathways.
This
article
provides
summary
major
involved
pathogenesis
emergence
disease's
phenotypic
features,
well
individualized
treatment
severe
subtypes
Language: Английский
Breath and Sputum Analyses in Asthmatic Patients: An Overview
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1355 - 1355
Published: Aug. 14, 2024
Recent
advancements
in
asthma
management
include
non-invasive
methodologies
such
as
sputum
analysis,
exhaled
breath
condensate
(EBC),
and
fractional
nitric
oxide
(FeNO).
These
techniques
offer
a
means
to
assess
airway
inflammation,
critical
feature
of
asthma,
without
invasive
procedures.
Sputum
analysis
provides
detailed
insights
into
inflammation
patterns
cellular
composition,
guiding
personalized
treatment
strategies.
EBC
collection,
reflecting
bronchoalveolar
lining
fluid
window
physiology.
FeNO
emerges
pivotal
biomarker,
offering
eosinophilic
aiding
diagnosis,
monitoring,
the
prediction
exacerbation
risks.
Despite
inherent
limitations,
each
method
offers
valuable
tools
for
more
comprehensive
assessment
asthma.
Combining
these
with
traditional
methods
like
spirometry
may
lead
plans
improved
patient
outcomes.
Future
research
is
crucial
refine
protocols,
validate
biomarkers,
establish
guidelines
order
enhance
tailored
therapeutic
strategies
Language: Английский
The Effect of a TLR3 Agonist on Airway Allergic Inflammation and Viral Infection in Immunoproteasome-Deficient Mice
Viruses,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1384 - 1384
Published: Aug. 29, 2024
Allergic
asthma
is
characterized
by
increased
type
2
inflammation,
including
eosinophils.
Subjects
with
allergic
have
recurrent
symptoms
due
to
their
constant
exposure
environmental
allergens,
such
as
house
dust
mite
(HDM),
which
can
be
further
exacerbated
respiratory
infections
like
rhinovirus.
The
immunoproteasome
(IP)
a
proteolytic
machinery
that
induced
inflammatory
mediators
during
virus
infection,
but
the
role
of
IP
in
airway
inflammation
rhinovirus
infection
remains
unknown.
Wild-type
(WT)
and
knockout
(KO)
mice
were
challenged
HDM.
At
48
h
after
last
HDM
challenge,
infected
1B
(RV-A1B)
for
24
h.
After
RV-A1B
treatment,
KO
(vs.
WT)
had
significantly
more
lung
eosinophils
neutrophils,
well
higher
viral
load,
less
IFN-beta
expression,
compared
WT
mice.
A
TLR3
agonist
polyinosinic-polycytidylic
acid
(Poly
I:C)
treatment
HDM-challenged
expression
reduced
minimal
effect
on
number
cells.
Our
data
suggest
an
important
mechanism
functioning
prevent
excessive
allergen-exposed
mice,
Poly
I:C
could
therapeutically
effective
enhancing
antiviral
response
lessening
burden
lungs
deficiency.
Language: Английский