Human Gut Microbiome in Heart Failure: Trying to Unmask an Emerging Organ DOI Open Access
Ioannis Paraskevaidis, Αndrew Xanthopoulos,

Elias Tsougkos

et al.

Published: Aug. 2, 2023

There is a bidirectional relationship between the heart and gut. Gut microbiome an excellent gut-homeostasis keeper since controls growth of potentially harmful bacteria protects microbiota environment. evidence suggesting that diet rich in fatty acid can be metabolized converted by gut hepatic enzymes to trimethyl-amine N-oxide (TMAO) product associated with atherogenesis, platelet dysfunction, thrombotic events, coronary artery disease, stroke, failure ultimately death. Heart failure, inducing ischemia congestion consequently barrier dysfunction promote intestinal leak microbes or even their products, facilitating entrance into circulation thus stimulating low-grade inflammation hence immune response. Drugs used for may alter microbiome, conversely modify pharmacokinetic properties drugs. Modification lifestyle based mainly on exercise Mediterranean along use pre- probiotics beneficial some extent The potential role development outcomes fruitful area future research.

Language: Английский

Oral Cardiac Drug–Gut Microbiota Interaction in Chronic Heart Failure Patients: An Emerging Association DOI Open Access
Ioannis Paraskevaidis, Αlexandros Briasoulis, Elias Tsougos

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1716 - 1716

Published: Jan. 31, 2024

Regardless of the currently proposed best medical treatment for heart failure patients, morbidity and mortality rates remain high. This is due to several reasons, including interaction between oral cardiac drug administration gut microbiota. The relation drugs (especially antibiotics) microbiota well established, but it also known that more than 24% non-antibiotic affect microbiota, altering microbe's environment its metabolic products. Heart lies mainly in blockage neuro-humoral hyper-activation. There debate as whether heart-failure-specific can totally block this hyper-activation, or so-called intestinal dysbiosis commonly observed group patients their action. Although there are reports indicating a strong drug-gut interplay, little about chronic failure. In review, we review contemporary data on topic infancy. We aim produce scientific thoughts questions provide reasoning further clinical investigation.

Language: Английский

Citations

6
Gut Microbiota in Heart Failure—The Role of Inflammation DOI Creative Commons
Petros Fountoulakis, Panagiotis Theofilis, Panayotis K. Vlachakis

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 911 - 911

Published: April 9, 2025

Heart failure (HF) has become an immense health concern affecting almost 1–2% of the population globally. It is a complex syndrome characterized by activation sympathetic nervous system and Renin–Angiotensin–Aldosterone (RAAS) axis as well endothelial dysfunction, oxidative stress, inflammation. The recent literature points towards interaction between intestinal flora heart, also called gut–heart axis. human gastrointestinal tract naturally inhabited various microbes, which are distinct for each patient, regulating functions many organs. Alterations gut microbiome, process dysbiosis, may result in systemic diseases have been associated with heart through inflammatory autoimmune mechanisms. disorder permeability favors translocation microbes metabolites capable inducing inflammation, thus further contributing to deterioration normal cardiac function. Besides diet modifications exercise training, studies revealed possible microbiota targeted treatments managing failure. aim this review demonstrate impact environment induced microbiome its on elucidation these novel therapeutic approaches.

Language: Английский

Citations

0
Gut–Kidney–Heart: A Novel Trilogy DOI Creative Commons
Mario Caldarelli, Laura Franza, Pierluigi Rio

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3063 - 3063

Published: Nov. 15, 2023

The microbiota represents a key factor in determining health and disease. Its role inflammation immunological disorders is well known, but it also involved several complex conditions, ranging from neurological to psychiatric, gastrointestinal cardiovascular diseases. It has recently been hypothesized that the gut may act as an intermediary close interaction between kidneys system, leading conceptualization of “gut–kidney–heart” axis. In this narrative review, we will discuss impact on each system while reviewing available data regarding axis itself. We describe metabolites interplay, potential therapeutical perspectives.

Language: Английский

Citations

6
Human Gut Microbiome in Heart Failure: Trying to Unmask an Emerging Organ DOI Open Access
Ioannis Paraskevaidis, Αndrew Xanthopoulos,

Elias Tsougkos

et al.

Published: Aug. 2, 2023

There is a bidirectional relationship between the heart and gut. Gut microbiome an excellent gut-homeostasis keeper since controls growth of potentially harmful bacteria protects microbiota environment. evidence suggesting that diet rich in fatty acid can be metabolized converted by gut hepatic enzymes to trimethyl-amine N-oxide (TMAO) product associated with atherogenesis, platelet dysfunction, thrombotic events, coronary artery disease, stroke, failure ultimately death. Heart failure, inducing ischemia congestion consequently barrier dysfunction promote intestinal leak microbes or even their products, facilitating entrance into circulation thus stimulating low-grade inflammation hence immune response. Drugs used for may alter microbiome, conversely modify pharmacokinetic properties drugs. Modification lifestyle based mainly on exercise Mediterranean along use pre- probiotics beneficial some extent The potential role development outcomes fruitful area future research.

Language: Английский

Citations

4