Unravelling Insights into the Evolution and Management of SARS-CoV-2: A Comprehensive Review DOI Open Access
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha

et al.

Published: Aug. 22, 2023

Worldwide, the COVID-19 pandemic, which was brought on by brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. Despite urgency, does not have any particular antiviral treatments at this time. As result, scientists are concentrating repurposing already existing medications or creating ones. The SARS-CoV-2 main protease, is necessary for viral replication, been identified as possible target family medicines called protease inhibitors (MPIs). Studies major proteases from SARS-CoV and MERS-CoV, remarkably similar structures functions to provided insight creation MPIs. By analyzing MPI trials review sheds light therapeutic uses MPIs COVID-19. talks about how work, effective they against safe are. paper also emphasizes current developments in including computational studies, vitro vivo research, clinical trials. According review, there lot hope treatment COVID-19, numerous works. Although more research needed assess their safety effectiveness settings, these may offer patients with much-needed option. importance ongoing into structure function information will be critical development other drugs future.

Language: Английский

Unravelling Insights into the Evolution and Management of SARS-CoV-2: A Comprehensive Review DOI Open Access
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha

et al.

Published: Aug. 22, 2023

Worldwide, the COVID-19 pandemic, which was brought on by brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. Despite urgency, does not have any particular antiviral treatments at this time. As result, scientists are concentrating repurposing already existing medications or creating ones. The SARS-CoV-2 main protease, is necessary for viral replication, been identified as possible target family medicines called protease inhibitors (MPIs). Studies major proteases from SARS-CoV and MERS-CoV, remarkably similar structures functions to provided insight creation MPIs. By analyzing MPI trials review sheds light therapeutic uses MPIs COVID-19. talks about how work, effective they against safe are. paper also emphasizes current developments in including computational studies, vitro vivo research, clinical trials. According review, there lot hope treatment COVID-19, numerous works. Although more research needed assess their safety effectiveness settings, these may offer patients with much-needed option. importance ongoing into structure function information will be critical development other drugs future.

Language: Английский

Citations

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