Nitric Oxide as a Determinant of Human Longevity and Health Span

Published: Sept. 1, 2023

The master molecular regulators and mechanisms determining longevity health span include nitric oxide (NO) superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between dangerous SOR protective radical to promote aging. Antioxidant supplementation orchestrates protection against oxidative stress damage—L-arginine antioxidants such as vitamin C increase production bioavailability. Uncoupling of generation with appearance be induced by asymmetric dimethylarginine (ADMA). L-arginine displace ADMA from site formation if sufficient amounts amino acid are available. Antioxidants ascorbic acids scavenge bioavailability NO. topics this review complex interactions antioxidant agents which determine bioactivity age-related degeneration.

Language: Английский

Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 11359 - 11374

Published: Oct. 13, 2024

While Ginsenoside Re has been shown to protect the central nervous system, reports of its effects on memory in model scopolamine-induced impairment are rare. The aim this study was investigate scopolamine (SCOP)-induced damage and mechanism action. Male ICR mice were treated with SCOP (3 mg/kg) for 7 days or without 14 days. As evidenced by behavioral studies (escape latency cross platform position), brain tissue morphology, oxidative stress indicators after treatment, caused significantly ameliorated. Further research indicated that inhibited cell apoptosis regulating PI3K/Akt/Nrf2 pathway, thereby exerting a cognitive improvement effect. This suggests could against SCOP-induced defects possibly through inhibiting apoptosis.

Language: Английский