Dynamics of Serum-Neutralizing Antibody Responses in Vaccinees through Multiple Doses of the BNT162b2 Vaccine
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(11), P. 1720 - 1720
Published: Nov. 15, 2023
SARS-CoV-2
mRNA
vaccines
are
administered
as
effective
prophylactic
measures
for
reducing
virus
transmission
rates
and
disease
severity.
To
enhance
the
durability
of
post-vaccination
immunity
combat
variants,
boosters
have
been
to
two-dose
vaccinees.
However,
long-term
humoral
responses
following
booster
vaccination
not
well
characterized.
A
16-member
cohort
healthy
naïve
participants
were
enrolled
in
this
study
during
a
three-dose
BNT162b2
vaccine
series.
Serum
samples
collected
from
vaccinees
over
420
days
screened
antigen
(Ag)-specific
antibody
titers,
IgG
subclass
distribution,
neutralizing
(nAb)
responses.
Vaccine
boosting
restored
peak
Ag-specific
titers
with
sustained
α-RBD
IgA
when
measured
at
six
months
post-boost.
RBD-
spike-specific
IgG4
levels
markedly
elevated
but
immune
sera.
Although
strong
neutralization
detected
two-
sera,
these
rapidly
decayed
pre-immune
by
four
months,
respectively.
While
enhanced
serum
Ab
reactivity
nAb
against
variant
strains,
all
variants
tested
showed
resistance
Our
data
reflect
poor
vaccine-induced
which
predictor
protection
symptomatic
infection.
The
induction
IgG4-switched
may
permit
extended
viral
persistence
via
downregulation
Fc-mediated
effector
functions.
Language: Английский
Comparison of Post-Vaccination Response (Humoral and Cellular) to BNT162b2 in Clinical Cases, Kidney and Pancreas Transplant Recipient with Immunocompetent Subjects over Almost Two Years of Parallel Monitoring
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 844 - 844
Published: July 26, 2024
Background:
Vaccination
is
one
of
the
most
effective
medical
interventions
to
prevent
infectious
diseases.
The
introduction
vaccines
against
coronavirus
acute
respiratory
syndrome
2
(SARS-CoV-2)
was
aimed
at
preventing
severe
illness
and
death
due
disease
2019
(COVID-19).
Solid
organ
transplant
recipients
(SOTRs)
are
high
risk
infection
with
SARS-CoV-2
serious
effects
associated
COVID-19,
mainly
use
immunosuppressive
therapies,
which
further
cause
suboptimal
response
COVID-19
vaccination.
Aim
study:
We
compare
post-vaccination
BNT162b2
in
kidney–pancreas
recipient,
specifically
immunocompetent
individuals,
over
two
years
simultaneous
monitoring.
Methods:
To
determine
humoral
response,
levels
IgG
IgA
anti-S1
antibodies
were
measured.
assess
cellular
SARS-CoV-2,
released
IFN-γ-S1
determinate.
Results
Conclusion:
After
primary
vaccination,
compared
subjects,
SOTR
showed
lower
seroconversion
for
both
antibody
classes.
Only
additional
dose
produced
level
reached
by
control
group
after
baseline
During
monitored
period,
did
not
achieve
a
positive
contrast
so
order
obtain
longer
protection,
including
immune
memory,
adoption
booster
doses
vaccine
should
be
considered.
Language: Английский