Audiological and Vestibular Follow-Up for Children with Congenital Cytomegalovirus Infection: From Current Limitations to Future Directions DOI Creative Commons
Mirko Aldè, Virginia Fancello, Paola Di Mauro

et al.

Children, Journal Year: 2024, Volume and Issue: 11(10), P. 1211 - 1211

Published: Oct. 1, 2024

Currently, the guidelines for audiological and vestibular follow-up in children with congenital cytomegalovirus (CMV) are not well-defined. The general recommendation is to evaluate hearing all CMV at same intervals: once every 3-6 months up 1 year of age, 6 from 3 years a age. Additionally, there no universally accepted protocols CMV, although video head impulse test (v-HIT) cervical vestibular-evoked myogenic potentials (cVEMPs) sometimes used. This narrative review critically evaluates existing approaches highlighting need personalized protocols. Tailoring schedules different timing methods based on risk factors, such as trimester maternal infection, PCR results amniotic fluid, valganciclovir use, would indeed allow more precise evaluations, timely interventions, optimized resource allocation. strategy also alleviate logistical emotional burdens families by ensuring that high-risk receive frequent appropriate assessments early while lower-risk avoid unnecessary testing.

Language: Английский

Acute Febrile Illness Accompanied by 7th and 12th Cranial Nerve Palsy Due to Lyme Disease Following Travel to Rural Ecuador: A Case Report and Mini-Review DOI Creative Commons
Teslin S. Sandstrom,

Kumudhavalli Kavanoor Sridhar,

J G Joshi

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(1), P. 21 - 21

Published: Jan. 14, 2025

The causative agent of Lyme disease, Borrelia burgdorferi, is endemic to Canada, the northeastern United States, northern California, and temperate European regions. It rarely associated with a travel-related exposure. In this report, we describe resident southern Ontario, Canada who developed rash, fever, cranial nerve VII XII palsies following 12 day trip Ecuador Galapagos islands approximately four weeks prior referral our center. Comprehensive microbiological work-up was notable for reactive burgdorferi serology by modified two-tier testing (MTTT), confirming diagnosis disease. This case highlights important teaching points, including classic clinical presentation acute disease compatible exposure pre-travel in Lyme-endemic region initial manifestations during travel acquisition arthropod bites Ecuador, more severe post-travel. Given history South American country which exceedingly uncommon, consideration infections acquired necessitated broad differential comprehensive than would have been required absence tropical travel. Additionally, involvement an uncommon feature neuroborreliosis, therefore warranted alternative, non-infectious etiology such as stroke or mass lesion, both were excluded patient through neuroimaging.

Language: Английский

Citations

0
The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review DOI Creative Commons
Antonino Maniaci, Marilena Briglia,

Fabio Allia

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 802 - 802

Published: Oct. 8, 2024

Inner ear disorders, including sensorineural hearing loss, Meniere’s disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, underlying pathophysiology these disorders remains elusive, current treatment options often inadequate. Emerging evidence suggests pericytes, a type vascular mural cell specialized to maintain integrity function microvasculature, may play crucial role in development progression inner disorders. The pericytes present microvasculature both cochlea system, where they regulate blood flow, blood–labyrinth barrier, facilitate angiogenesis, provide trophic support neurons. Understanding valuable insights into lead novel diagnostic therapeutic strategies, improving standard living. This comprehensive review aims detailed overview highlighting anatomy physiology analyzing mechanisms contribute Furthermore, we explore potential pericyte-targeted therapies, antioxidant, anti-inflammatory, angiogenic approaches, as well gene therapy strategies.

Language: Английский

Citations

2
Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis DOI Open Access

Zhengdong Zhao,

Xiaozhou Liu,

Yanjun Zong

et al.

Published: Dec. 1, 2023

Herpesvirus is a prevalent pathogen that primarily infects human epithelial cells and has the ability to reside in neurons. In field of otolaryngology, herpesvirus infection leads hearing loss vestibular neuritis, considered primary hypothesis regarding pathogenesis neuritis. this review, we provide summary effects herpes virus on cellular processes both host immune cells, with focus HSV-1 as illus-trative examples.

Language: Английский

Citations

5
Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years DOI Open Access
Mirko Aldè, Umberto Ambrosetti, G. Piatti

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3303 - 3303

Published: June 4, 2024

Objectives: The purpose of this study was to investigate the hearing characteristics and causes sudden sensorineural loss (SSNHL) in patients aged from 15 40 years, focusing on audiological outcomes one year after diagnosis. Methods: medical records individuals with SSNHL who were referred our tertiary-level audiologic center reviewed. All had undergone comprehensive diagnostic evaluations, including high-resolution 3D-FLAIR delayed magnetic resonance imaging (MRI), cone beam computed tomography (CBCT), screening for coagulation, infectious, autoimmune diseases. Results: Overall, 56 (mean age 28.1 ± 7.6 years) included study. threshold affected ear improved significantly 56.0 18.0 dB at diagnosis 46.9 22.3 (p = 0.02). degree loss, audiometric configurations, improvements, adherence treatments showed considerable variability among patients. Aural fullness, tinnitus, hyperacusis predominant symptoms associated SSNHL, their prevalence decreased over time. protocol led identification specific cause 75% (42/56) known etiology found be otological (39.3%), infectious (21.4%), (7.1%), vascular (5.4%), or neoplastic (1.8%). In particular, Menière's disease (n 12), isolated cochlear endolymphatic hydrops 6), HSV-1 5), EBV 4) infections most frequent SSNHL. Conclusions: may facilitate a more personalized approach management treatment.

Language: Английский

Citations

1
Audiological and Vestibular Follow-Up for Children with Congenital Cytomegalovirus Infection: From Current Limitations to Future Directions DOI Creative Commons
Mirko Aldè, Virginia Fancello, Paola Di Mauro

et al.

Children, Journal Year: 2024, Volume and Issue: 11(10), P. 1211 - 1211

Published: Oct. 1, 2024

Currently, the guidelines for audiological and vestibular follow-up in children with congenital cytomegalovirus (CMV) are not well-defined. The general recommendation is to evaluate hearing all CMV at same intervals: once every 3-6 months up 1 year of age, 6 from 3 years a age. Additionally, there no universally accepted protocols CMV, although video head impulse test (v-HIT) cervical vestibular-evoked myogenic potentials (cVEMPs) sometimes used. This narrative review critically evaluates existing approaches highlighting need personalized protocols. Tailoring schedules different timing methods based on risk factors, such as trimester maternal infection, PCR results amniotic fluid, valganciclovir use, would indeed allow more precise evaluations, timely interventions, optimized resource allocation. strategy also alleviate logistical emotional burdens families by ensuring that high-risk receive frequent appropriate assessments early while lower-risk avoid unnecessary testing.

Language: Английский

Citations

1