Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

Published: Jan. 15, 2025

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Language: Английский

Brain Stars Take the Lead during Critical Periods of Early Postnatal Brain Development: Relevance of Astrocytes in Health and Mental Disorders

Published: March 13, 2024

In the brain, astrocytes regulate shape and functions of synaptic vascular compartments through a variety released factors membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to onset severe pathologies. Clinical pre-clinical studies show alterations in cell number, morphology, molecular makeup astrocyte-dependent processes different affected regions neurodevelopmental (ND) neuropsychiatric (NP) disorders. Astrocytes proliferate, differentiate mature during critical period early postnatal time window elevated glia-dependent regulation proper balance between synapse formation/elimination, which is pivotal refining connectivity. Therefore, any intrinsic and/or extrinsic altering these may result an aberrant remodelling mental The peculiar bridging position further allows them “compute” state consequently secrete bloodstream, serve as diagnostic biomarkers distinct healthy or disease conditions.Here, we collect recent advancements regarding astrogenesis astrocyte-mediated neuronal network periods focusing elimination. We then propose alternative hypotheses for involvement aberrancies ND NP light well-known differential prevalence certain disorders males females, also discuss putative sex-dependent influences events.From translational perspective, understanding age- astrocyte-specific functional changes help identify cellular (dys)functions health disease, favouring development tools selection tailored treatment options male/female patients.

Language: Английский

Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation

eLife, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Early-life stress can have lifelong consequences, enhancing susceptibility and resulting in behavioural cognitive deficits. While the effects of early-life on neuronal function been well-described, we still know very little about contribution non-neuronal brain cells. Investigating complex interactions between distinct cell types is critical to fully understand how cellular changes manifest as deficits following stress. Here, using male female mice report that induces anxiety-like behaviour fear generalisation an amygdala-dependent learning memory task. These were associated with impaired synaptic plasticity, increased neural excitability, astrocyte hypofunction. Genetic perturbation amygdala by either reducing calcium activity or network was sufficient replicate cellular, synaptic, Our data reveal a role astrocytes tuning emotionally salient provide mechanistic links stress, hypofunction,

Language: Английский