HLA-DQ2/8 and COVID-19 in celiac disease: Boon or Bane

Published: Nov. 17, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ 2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these 2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA 2/8, suggesting effect. various mechanisms might explain role HLA-DQ2/8 in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Language: Английский

Association of Human Leukocyte Antigen Alleles with COVID-19 Severity and Mortality in a Spanish Population

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1392 - 1392

Published: Aug. 25, 2024

: The aim of the following cross-sectional study is to determine association between human leukocyte antigen (HLA) alleles and outcomes in patients presenting emergency department (ED) with SARS-CoV-2 infection.

Language: Английский