Published: Aug. 20, 2024
Historically, macrophages have been long implicated in the control of severity infectious diseases. This has based on observations a higher risk severe disease and death upon rechallenge with viral variants due to antibody dependent enhance-ment (ADE) infection into macrophages. The question remains as what can account for this potent heterologous protection macrophages? Here it is argued that elusive defense mechanism M1-like pro-inflammatory may pertain novel virus anti-virus response. system initiates high replication human endogenous retrovirus K102 (HERV-K102), non-pathogenic, protector foamy humans which generates macrophages, glycolysis, epigenetic changes, all characteristic trained immunity. virus-anti-virus kills virally infected cells by several mechanisms, amplifies innate interferon response via ‘viral mimicry’, many unique components interfere exoge-nous replication, be especially adept at neutralizing enveloped exogenous pandemic viruses, such SARS-CoV-2 HIV-1. goal treatise introduce multifaceted HERV-K102 system, illustrate how target ADE, explore exploited preparedness.
Language: Английский