Antivirals and Biologics for Broader Coverage Against Human Coronaviruses DOI Open Access

Mia Outteridge,

Christine M. Nunn,

Kevin M. Devine

et al.

Published: Dec. 12, 2023

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome 27-31kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and 9 accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles replication cycle immune evasion (1). There 7 known human CoVs most likely appeared after zoonotic transfer, recent being SARS-CoV-2 responsible Covid-19 pandemic. Antivirals been approved by FDA use against such as Paxlovid can potentially target successfully inhibit main protease (MPro) activity of CoVs, however alternative proteomes encoded CoV genomes closer genetic similarity to each other, suggesting antivirals could be developed now future CoVs. New introductions humans inevitable unpredictable. Therefore, new required control not only next outbreak, but also 4 common (229E, OC43, NL63, HKU1) circulate frequently contain sporadic outbreaks severe (SARS-CoV, MERS SARS-CoV-2). The current study found emerging antiviral drugs, Paxlovid, proven SARS-CoV-2. Other drugs which potential other still within clinical trial yet available public use. Monoclonal antibody (mAb) treatment vaccines reduce mortality hospitalisation rates, they Spike protein whose sequence mutates drifts. is applicable targeting HCoVs these well conserved sequences among Thus, there need readily treatments globally all improve preparedness outbreaks. Here we discuss research contributing transmission, including outbreak. aim was identify features antivirals, biologics scientific, political, economic health strain caused future.

Language: Английский

Antivirals and Biologics for Broader Coverage Against Human Coronaviruses DOI Open Access

Mia Outteridge,

Christine M. Nunn,

Kevin M. Devine

et al.

Published: Dec. 12, 2023

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome 27-31kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and 9 accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles replication cycle immune evasion (1). There 7 known human CoVs most likely appeared after zoonotic transfer, recent being SARS-CoV-2 responsible Covid-19 pandemic. Antivirals been approved by FDA use against such as Paxlovid can potentially target successfully inhibit main protease (MPro) activity of CoVs, however alternative proteomes encoded CoV genomes closer genetic similarity to each other, suggesting antivirals could be developed now future CoVs. New introductions humans inevitable unpredictable. Therefore, new required control not only next outbreak, but also 4 common (229E, OC43, NL63, HKU1) circulate frequently contain sporadic outbreaks severe (SARS-CoV, MERS SARS-CoV-2). The current study found emerging antiviral drugs, Paxlovid, proven SARS-CoV-2. Other drugs which potential other still within clinical trial yet available public use. Monoclonal antibody (mAb) treatment vaccines reduce mortality hospitalisation rates, they Spike protein whose sequence mutates drifts. is applicable targeting HCoVs these well conserved sequences among Thus, there need readily treatments globally all improve preparedness outbreaks. Here we discuss research contributing transmission, including outbreak. aim was identify features antivirals, biologics scientific, political, economic health strain caused future.

Language: Английский

Citations

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