Correlation of Pseudomonas aeruginosa Phage Resistance with Numbers and Types of Antiphage Systems DOI Open Access
Kevin A. Burke, Caitlin D. Urick, Nino Mzhavia

et al.

Published: Dec. 18, 2023

Phage therapeutics offer a potentially powerful approach to combat multidrug-resistant bacterial infections. However, be effective, phage therapy must overcome existing and developing resistance. While cocktails can reduce this risk by targeting multiple receptors in single therapeutic, bacteria have mechanisms of resistance beyond receptor modification. A rapidly growing body knowledge describes broad varied arsenal antiphage systems encoded counter infection. We sought understand the types frequencies present highly diverse panel Pseudomonas aeruginosa clinical isolates utilized characterize novel antibacterials. Using web-server tool PADLOC (Prokaryotic Antiviral Defense Locator), putative were identified these P. based on sequence homology validated curated catalog known defense systems. Coupling host bacterium analysis with range data for 70 phages, we observed correlation between presence higher numbers genomes. also able identify that more prevalent phage-resistant strains, suggesting their importance conferring

Language: Английский

Correlation of Pseudomonas aeruginosa Phage Resistance with Numbers and Types of Antiphage Systems DOI Open Access
Kevin A. Burke, Caitlin D. Urick, Nino Mzhavia

et al.

Published: Dec. 18, 2023

Phage therapeutics offer a potentially powerful approach to combat multidrug-resistant bacterial infections. However, be effective, phage therapy must overcome existing and developing resistance. While cocktails can reduce this risk by targeting multiple receptors in single therapeutic, bacteria have mechanisms of resistance beyond receptor modification. A rapidly growing body knowledge describes broad varied arsenal antiphage systems encoded counter infection. We sought understand the types frequencies present highly diverse panel Pseudomonas aeruginosa clinical isolates utilized characterize novel antibacterials. Using web-server tool PADLOC (Prokaryotic Antiviral Defense Locator), putative were identified these P. based on sequence homology validated curated catalog known defense systems. Coupling host bacterium analysis with range data for 70 phages, we observed correlation between presence higher numbers genomes. also able identify that more prevalent phage-resistant strains, suggesting their importance conferring

Language: Английский

Citations

1