Published: Dec. 19, 2023
Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for controlling the unbridled growth of cells, thus preventing formation cancerous tissues. CI can be further categorized into two distinct yet interrelated components: locomotion (CIL) and proliferation (CIP). These components have historically been viewed as separate processes, but emerging research indicates that they share both distinctive common pathways. Moreover, exhibit intriguing intersections with mechanotransduction, process involves cells sensing responding to mechanical forces. This review article describes intricate interplay between forces CI, shedding light on how these regulate CIL CIP. Emphasis is placed filamin A (FLNA)-mediated elucidating FLNA senses translates them biochemical signals cell proliferation. In addition FLNA, trans-acting factors (TAFs) emerge sensitive players in mechanotransduction process. presents methods identifying TAFs profiling associated changes chromatin structure, offering valuable insights regulation. Finally, it addresses unanswered questions fields delineates their possible future directions.
Language: Английский