Pollution by Antimicrobials and Antibiotic Resistance Genes in East Africa: Occurrence, Sources, and Potential Environmental Implications

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101969 - 101969

Published: Feb. 22, 2025

Language: Английский

Community case study: an academia-industry-government partnership that monitors and predicts outbreaks in Tri-County Detroit area since 2017

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 28, 2025

The Tri-County Detroit Area (TCDA) is the 12th most populous metropolitan area in United States with over three million people. Multiple communicable diseases are endemic TCDA. In 2017, to explore innovative methods that may provide early warnings of outbreaks affecting populations TCDA, an exploratory partnership was funded by a U.S. National Science Foundation Early-concept Grant for Exploratory Research (EAGER) began. Since project team including College Engineering at Michigan State University (MSU), City Detroit, Great Lakes Water Authority (GLWA), industry, and local government health departments, has been testing municipal wastewater from TCDA survey predict surges area. This ongoing effort started years before wastewater-based epidemiology became widespread method public practice, due COVID-19 pandemic, now supported Centers Disease Control Prevention (CDC). work led significant breakthroughs field surveillance/wastewater epidemiology. results our surveillance efforts used assist departments their understanding response issues facilitating messaging awareness, targeted clinical testing, increased vaccination efforts. Our data available methodological advancements published have other communities nationwide beyond. paper describes partnership, lessons learned, achievements, provides look into future. successful implementations advocate importance frequent communications interactions within idea generations each stakeholder decision-making, maintenance scientific rigor, ethical more.

Language: Английский

Strengthening Pathogen and Antimicrobial Resistance Surveillance by Environmental Monitoring in Sub-Saharan Africa: A Stakeholder Survey

Published: Feb. 5, 2024

Background: Waterborne diseases pose a significant global public health threat, compelling enhanced comprehensive surveillance. This study investigates the current infectious disease and antimicrobial resistance (AMR) surveillance systems, including wastewater environmental (WES), in three sub-Saharan African countries: Tanzania, Burkina Faso, Democratic Republic of Congo (DRC). The countries have their specificities regarding networks logistic systems. So, emphasizing need to strengthen existing surveillance, paper advocates for incorporating WES systems specifically designed countries' context monitor waterborne re-emerging pathogens, as well AMR.Methods: National workshops were conducted assess clinical identify priority pathogens new monitoring. Data collected through surveys from experts academia, research, policy, healthcare. Results: Prioritized include (poliovirus, Salmonella Typhi, Vibrio cholerae), respiratory (influenza A&B, SARS-CoV-2), other (Measles Rubella, Mycobacterium tuberculosis). Recommended AMR drug-resistant tuberculosis, spp., methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase carbapenemase-producing E. coli. DRC employ DHSI2-based centralized electronic data collection, complemented by Excel paper-based registries. approach is commonly employed monitoring poliovirus rarely pathogens. Discussion conclusions: valuable tool early detection locally circulating human-derived aiding outbreak detection, data-driven epidemic response, prevention. availability results underscores importance effective sanitation safeguarding human, animal, health. pivotal integrated risk management, preventing outbreaks, protecting drinking water sources, ultimately gaining various UN Sustainable Development Goals. highlights customized line with each country's context, localized approaches AMR.

Language: Английский