Development and Perfection of Marine-Based Insecticide Biofilm for Pea Seed Protection: Experimental and Computational Approaches DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif,

My Ismail El Mhamdi,

Ayoub Ainane

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1621 - 1621

Published: April 4, 2025

This work aims to develop an insecticidal biofilm based on Calothrixin A, collagen, and chitosan for the protection of pea seeds. The main objective is improve ingredient concentrations maximizing activity study desorption A according diffusion parameters. Eight formulations were prepared with different components tested Sitona lineatus Bruchus pisorum. results show that a high concentration tended increase activity, although this was not always significant, while higher collagen reduced probably by limiting active ingredient. prediction models showed interaction factors had no significant impact responses, but model presented better accuracy. tests revealed CB3C-5 biofilm, parameters, correlated activity. characterization adequate physical, mechanical, thermal, structural properties agricultural seed storage application. Moreover, computational approach interacts more efficiently OR5-Orco complex than small OBP, disrupting olfactory detection insects. mechanism highlights targeting as potential strategy control insect pests. research contributes understanding role marine-based biofilms opens perspectives development ecological solutions against pests, particularly in field sustainable agriculture.

Language: Английский

Advanced Formulation of Ecological Bioinsecticides Based on Citrus limonum in Clayey Matrices: Optimization of Diffusive Dynamics DOI Open Access
Fatouma Mohamed Abdoul‐Latif, Ayoub Ainane,

Houda Mohamed

et al.

Sustainability, Journal Year: 2025, Volume and Issue: 17(2), P. 785 - 785

Published: Jan. 20, 2025

This study investigates the innovative use of natural porous clays from Bejaad Region in Morocco as a support matrix for encapsulation and controlled release lemon essential oil (Citrus limonum, EOCL), compound with well-documented insecticidal properties. The research aims to address inherent challenges oils, particularly their high volatility rapid degradation, by improving stability efficiency against grain pest Sitophilus granarius. By anchoring EOCL onto clay matrices, this seeks achieve sustained active components, thereby enhancing practical application biopesticides. were comprehensively characterized using advanced analytical techniques, including X-ray diffraction (XRD), fluorescence (XRF), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy energy-dispersive analysis (SEM-EDX), thermogravimetric (TGA). These techniques revealed mineralogical composition, thermal properties, morphology clays, demonstrating suitability effectively adsorbing retaining EOCL. performance clay/EOCL composites was thoroughly tested under conditions, revealing marked improvement efficacy, significantly lower lethal doses required mortality rates diffusion through modeled Fick’s law diffusion, results further refined statistical optimization identify key parameters that influence effectiveness compounds. Complementing experimental approach, bioinformatics conducted explore molecular interactions between limonene, primary component EOCL, target proteins insects. theoretical investigation provided insights into potential mechanisms action, reinforcing empirical findings. concludes encapsulating within matrices not only enhances but also boosts its effectiveness. approach presents promising, environmentally sustainable strategy crop protection, integrating material science, modeling, develop more efficient durable

Language: Английский

Citations

1
Assessment and Optimization of the Insecticidal Properties of γ-Al2O3 Nanoparticles Derived from Mentha pulegium By-Products against Xylosandrus crassiusculus (Carob Beetle) DOI Open Access
Fatouma Mohamed Abdoul‐Latif, Ayoub Ainane, Fatima-Ezzahra Eddabbeh

et al.

Published: Jan. 29, 2024

This study concentrates on assessing the insecticidal attributes of γ-Al2O3 nanoparticles derived from remnants Mentha pulegium, which include essential oil, ethanolic extract, and plant waste. The synthesis was executed via a direct sol-gel procedure, affirming crystal structure through extensive physicochemical analyses such as UV-VIS, XRD, FTIR, SEM. evaluation activity in vitro conducted against Xylosandrus crassiusculus, pest that infests carob wood, utilizing strains diverse forests Khenifra region, situated Moroccan Middle Atlas. lethal doses 50 ranged 40 mg/g to 68 mg/g, indicating moderate effectiveness compared commercial insecticide Permethrin. optimization conditions for efficiency determined by experimental plans, revealing time, humidity, temperature were influential factors dose these nanomaterials. Moreover, this encompasses establishment correlations Principal Component Analysis (PCA) Ascending Hierarchical Classification (AHC) among various geographic, biological, physical data, amalgamating geographic altitude, nanoparticle parameters, well mechanical tests wood affected insects. correlation highlights close connection between insecticide, mountain parameters examined. Ultimately, demonstrate promising potential alternative insecticides, thus opening encouraging prospects safeguarding pests.

Language: Английский

Citations

4
Cynthichlorine Extracted from Ascidian Cynthia savignyi from Djibouti: Optimization of Extraction, In Vitro Anticancer Profiling, and In Silico Approach DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif,

Houda Mohamed,

Ibrahim Houmed Aboubaker

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 172 - 172

Published: April 16, 2025

This work focuses on the extraction of cynthichlorine from ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize conditions and evaluate cytotoxic activity in tumor cell lines. Two methods, maceration Soxhlet extraction, were compared, with showing significantly higher yield (2.2 ± 0.2%) compared (1.0 0.2%). An optimization factors influencing performed using Box–Behnken method, temperature time have negative impact yield, optimal being below 25 °C those 12 h. Cytotoxic assessment revealed marked inhibition growth all tested lines (U87-MG, U2OS, NCI-N87, HCT116, A2780), IC50 values ranging 0.162 µg/mL U87-MG 0.576 NCI-N87. Finally, computational analysis showed exhibits high electronic stability notable affinity for some biological targets, including NM23-H2, suggesting its targeted therapy cancer treatment. These results pave way future studies therapeutic use cynthichlorine.

Language: Английский

Citations

0
Development and Perfection of Marine-Based Insecticide Biofilm for Pea Seed Protection: Experimental and Computational Approaches DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif,

My Ismail El Mhamdi,

Ayoub Ainane

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1621 - 1621

Published: April 4, 2025

This work aims to develop an insecticidal biofilm based on Calothrixin A, collagen, and chitosan for the protection of pea seeds. The main objective is improve ingredient concentrations maximizing activity study desorption A according diffusion parameters. Eight formulations were prepared with different components tested Sitona lineatus Bruchus pisorum. results show that a high concentration tended increase activity, although this was not always significant, while higher collagen reduced probably by limiting active ingredient. prediction models showed interaction factors had no significant impact responses, but model presented better accuracy. tests revealed CB3C-5 biofilm, parameters, correlated activity. characterization adequate physical, mechanical, thermal, structural properties agricultural seed storage application. Moreover, computational approach interacts more efficiently OR5-Orco complex than small OBP, disrupting olfactory detection insects. mechanism highlights targeting as potential strategy control insect pests. research contributes understanding role marine-based biofilms opens perspectives development ecological solutions against pests, particularly in field sustainable agriculture.

Language: Английский

Citations

0