The Redox Homeostasis Alteration Is Restored by Melatonin Treatment in COVID-19 Patients
Published: Jan. 31, 2024
Type
II
pneumocytes
are
the
target
of
SARS-CoV-2
which
alters
their
redox
homeostasis
to
increase
reactive
oxygen
species
(ROS).
Melatonin
(MT)
has
antioxidant
proprieties
and
protects
mitochondrial
function.
Here
we
evaluated
whether
treatment
with
MT
compensated
for
alteration
in
serum
from
COVID-19
patients.
We
determined
oxidative
stress
(OS)
markers
such
as
carbonyls,
glutathione
(GSH),
total
capacity
(TAC),
thiols,
nitrites
(NO2–),
lipid
peroxidation
(LPO),
thiols
groups
serum.
also
studied
enzymatic
activities
peroxidase
(GPx),
-S-transferase
(GST),
reductase
(GR),
thioredoxin
(TrxR),
extracellular
superoxide
dismutase
(ecSOD)
peroxidases.
There
was
a
significant
LPO
carbonyls
(p≤0.03)
decrease
TAC,
NO2–,
GSH,
(p<0.001)
The
ecSOD,
TrxR,
GPx,
GST,
GR
peroxidases
were
decreased
(p≤
0.04).
favored
activity
enzymes
contributed
TAC
restored
lost
homeostasis.
modulated
glucose
functioning
glycolytic
agent
inhibited
Warburg
effect.
Thus,
restores
is
altered
patients
can
be
used
adjuvant
therapy
infection.
Language: Английский
The Physiological Impact of Melatonin, Its Effect on the Course of Diseases and Their Therapy and the Effect of Magnetic Fields on Melatonin Secretion—Potential Common Pathways of Influence
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(8), P. 929 - 929
Published: July 31, 2024
Melatonin
is
a
relic,
due
to
its
millions-of-years-old
presence
in
chemical
reactions,
found
evolutionarily
diverse
organisms.
It
has
multidirectional
biological
function.
controls
diurnal
rhythms,
redox
homeostasis,
intestinal
motor
functions,
mitochondrial
biogenesis
and
fetal
development
antioxidant
effects.
also
analgesic
therapeutic
The
purpose
of
this
paper
describe
the
role
melatonin
vital
processes
occurring
interaction
with
environment,
particular
reference
various
magnetic
fields
ubiquitous
life
animate
matter,
especially
radio
frequency/extra
low
frequency
(RF/ELF
EMF)
static
fields.
most
important
part
article
potential
effects
on
secretion
resulting
possible
health
some
cases
positively
amplifies
electromagnetic
signal,
intensifying
effects,
such
as
neurogenesis,
or
lowering
blood
pressure.
In
other
cases,
it
stimulus
that
inhibits
destruction
aggravation
lesions.
Sometimes,
however,
contrast
beneficial
therapy,
they
intensify
pathogenic
multiple
sclerosis
by
inflammatory
process.
Language: Английский
Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(7), P. 7219 - 7238
Published: July 8, 2024
SARS-CoV-2
is
an
obligatory
intracellular
pathogen
that
requires
a
lipid
bilayer
membrane
for
its
transport
to
build
nucleocapsid
envelope
and
fuse
with
the
host
cell.
The
biological
membranes
are
constituted
by
phospholipids
(PLs),
vitamin
E
(Vit
E)
protects
them
from
oxidative
stress
(OS).
aim
of
this
study
was
demonstrate
if
treatment
Vit
restores
modified
profile
FA
in
PLs
serum
patients
coronavirus
disease-19
(COVID-19).
We
evaluated
E,
total
fatty
acids
(TFAs),
(FAPLs),
(TPLs),
8-isoprostane,
thromboxane
B
Language: Английский