Published: Feb. 14, 2024
Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; import (e.g., from blood-borne lipoproteins); export. In complex tissues, composed of multiple different cell types (such as the retina), export also may involve intra-tissue, inter-cellular exchange. Disruption any these processes can result pathologies that impact normal structure function retina. Here, we provide a brief overview what is known currently about vertebrate retina offer proposed path for future experimental work to further our understanding processes, with relevance development novel therapeutic interventions human diseases involving defective homeostasis.
Language: Английский