Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation
Published: Feb. 7, 2024
Adipose
tissue
undergoes
changes
with
aging,
leading
to
increased
adiposity,
inflammatory
cell
infiltration,
reduced
angiogenesis,
heightened
oxidative
stress,
and
alterations
in
its
metabolic
function.
Regular
exercise
has
been
recognized
as
a
powerful
intervention
that
can
positively
influence
adipose
health
mitigate
the
effects
of
aging.
However,
molecular
mechanisms
underlying
benefits
regular
on
aging
function
remain
poorly
understood.
Adipokines
released
through
play
potential
role
mitigating
enhancing
metabolism
glucose
lipids,
reducing
inflammation
fibrosis,
promoting
fat
browning
thermogenesis.
The
goal
this
review
is
offer
comprehensive
overview
addressing
age-related
decline
significance
disorders
associated
aged
will
be
discussed.
Language: Английский
Molecular bases of adipose tissue aging
Published: Feb. 14, 2025
Aging
impacts
each
and
every
living
organism.
In
higher
organisms,
it
is
an
asynchronous
process
with
its
onset
pace
varying
among
tissue
types
as
well
different
cell
within
a
tissue.
Adipose
the
largest
energy
depot
in
body
endocrine
organ
responsible
for
metabolic
homeostasis.
aging
marked
by
fat
redistribution,
increased
visceral
reduced
subcutaneous
observed
we
age.
At
molecular
level,
adipose
multifaceted
driven
diverse
mechanisms,
involving
dysregulated
adipogenic
pathways,
impaired
thermogenesis,
regeneration,
of
senescence,
emergence
inflammation.
Dysregulated
pathways
introduce
dysfunction
compromising
lipid
metabolism,
leading
to
complications
such
insulin
resistance
diabetes.
addition,
beige
brown
further
aggravates
scenario
impacting
thermogenesis.
Moreover,
decline
regenerative
potential
due
loss
function
APSCs
limits
adipogenesis.
Onset
senescence
disrupts
local
homeostasis
impairing
cellular
increasing
stress.
Chronic
inflammation
extends
effects
beyond
disruption,
contributing
systemic
imbalances.
Here,
discuss
our
current
understanding
mechanisms
driving
aging,
highlighting
their
implications
health.
Interventions,
as,
senolytics,
pharmacological
modulators,
tissue-specific
approaches
offer
promising
avenues
mitigating
aging-related
Identifying
therapeutic
targets
clinical
translation
preserving
crucial
associated
aging.
Language: Английский
The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(5), P. 287 - 287
Published: May 17, 2024
There
is
a
notable
correlation
between
mitochondrial
homeostasis
and
metabolic
disruption.
In
this
review,
we
report
that
obesity-induced
disruption
of
adversely
affects
lipid
metabolism,
adipocyte
differentiation,
oxidative
capacity,
inflammation,
insulin
sensitivity,
thermogenesis
in
thermogenic
fat.
Elevating
fat
emerges
as
promising
avenue
for
developing
treatments
diseases,
including
enhanced
function,
mitophagy,
uncoupling,
biogenesis.
The
exerkines
(e.g.,
myokines,
adipokines,
batokines)
released
during
exercise
have
the
potential
to
ameliorate
homeostasis,
improve
glucose
stimulate
browning
defense
against
obesity-associated
diseases.
This
comprehensive
review
focuses
on
manifold
benefits
exercise-induced
exerkines,
particularly
emphasizing
their
influence
context
disorders
associated
with
obesity.
Language: Английский