Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2646 - 2646
Published: Nov. 20, 2024
Schizophrenia
is
a
complex
disorder
characterized
by
positive
symptoms
(e.g.,
hallucinations),
negative
social
withdrawal),
and
disorganized
thought
disorder).
Alongside
these,
cognitive
depressive
often
emerge,
with
sometimes
dominating
the
clinical
picture.
Understanding
factors
that
influence
development
of
in
schizophrenia
could
clarify
dynamics
between
psychotic
guide
interventions.
Cells,
Journal Year:
2024,
Volume and Issue:
13(10), P. 790 - 790
Published: May 7, 2024
Translational
research
in
neurological
and
psychiatric
diseases
is
a
rapidly
advancing
field
that
promises
to
redefine
our
approach
these
complex
conditions
[...]
Cells,
Journal Year:
2024,
Volume and Issue:
13(13), P. 1098 - 1098
Published: June 25, 2024
Migraine
is
a
debilitating
neurological
disorder
characterized
by
recurring
episodes
of
throbbing
headaches
that
are
frequently
accompanied
sensory
disturbances,
nausea,
and
sensitivity
to
light
sound
[...]
The
central
nervous
system
(CNS)
is
the
final
frontier
in
drug
delivery
because
of
blood-brain
barrier
(BBB),
which
poses
significant
barriers
to
access
most
drugs
their
targets.
Kynurenic
acid
(KYNA),
a
tryptophan
(Trp)
metabolite,
plays
an
important
role
behavioral
functions
and
abnormal
KYNA
levels
have
been
observed
neuropsychiatric
conditions.
current
challenge
lies
delivering
CNS
owing
its
polar
side
chain.
Recently,
C-3
chain
modified
analogs
shown
cross
BBB;
however,
it
unclear
whether
they
retain
biological
parent
molecule.
This
study
examined
impact
analogs,
specifically
SZR-72,
SZR-104,
newly
developed
SZRG-21,
on
behavior.
were
administered
intracerebroventricularly
(i.c.v.),
effects
motor
domain
compared
with
those
KYNA.
Specifically,
open
field
(OF)
rotarod
(RR)
tests
employed
assess
activity
skills.
SZR-104
increased
horizontal
exploratory
OF
test
at
dose
0.04
μmol/4
μL,
while
SZR-72
decreased
vertical
doses
0.1
μL.
In
RR
test,
neither
nor
showed
any
differences
skills
either
dose.
Side
modification
affects
affective
performance
behavior,
as
results
show
for
first
time.
this
study,
we
that
alter
emotional
components
such
motor-associated
curiosity
emotions.
Consequently,
design
necessitates
development
precise
strategies
traverse
BBB
paying
close
attention
modifications
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 701 - 701
Published: June 7, 2024
With
neurodegenerative
disorders
being
on
the
rise,
a
great
deal
of
research
from
multiple
fields
is
conducted
in
order
to
further
knowledge
and
propose
novel
therapeutic
interventions.
Among
these
investigations,
role
antioxidants
contrasting
cognitive
decline
putting
forward
interesting
promising
results.
In
this
review,
we
aim
collect
evidence
that
focused
variety
antioxidant-rich
foods
improving
or
stabilizing
functions,
memory,
Alzheimer’s
disease,
most
common
disorder.
Specifically,
considered
collected
humans,
either
through
longitudinal
studies
randomized,
placebo-controlled
ones,
which
evaluated
performance,
memory
abilities,
progression
level
neurodegeneration.
Overall,
despite
between
study
protocols,
cohorts
participants
involved,
neuropsychological
tests
used,
investigated
antioxidants,
there
solid
trend
suggests
properties
may
be
helpful
hampering
older
people.
Thus,
help
future
will
elucidate
neuroprotection
lead
development
interventions
take
into
account
such
findings
provide
more
global
approach
treating
disorders.
The
triad
of
vascular
impairment,
muscle
atrophy,
and
cognitive
decline
represents
critical
age-related
conditions
that
significantly
impact
health.
Vascular
impairment
disrupts
blood
flow,
precipitating
mass
reduction
seen
in
sarcopenia
the
neuronal
functions
characteristic
neurodegeneration.
Our
limited
understanding
intricate
relationships
within
this
hinders
accurate
diagnosis
effective
treatment
strategies.
This
review
ana-lyzes
interrelated
mechanisms
contribute
to
these
conditions,
with
a
specific
focus
on
ox-idative
stress,
chronic
inflammation,
impaired
nutrient
delivery.
aim
is
understand
common
pathways
involved
suggest
comprehensive
therapeutic
approaches.
dysfunctions
hinder
circulation
transportation
nutrients,
resulting
sar-copenia
characterized
by
atrophy
weakness.
dysfunction
have
negative
physical
function
quality
life.
Neurodegenerative
diseases
exhibit
comparable
pathophysiological
affect
motor
functions.
Preventive
approaches
encompass
lifestyle
adjustments,
addressing
oxidative
in-flammation,
integrated
therapies
improving
muscular
well-being.
Better
links
can
refine
strategies
yield
better
patient
out-comes.
study
emphasizes
complex
interplay
between
dysfunction,
de-generation,
decline,
highlighting
necessity
for
multidisciplinary
ap-proaches.
Advances
domain
promise
improved
diagnostic
accuracy,
more
thera-peutic
options,
enhanced
preventive
measures,
all
contributing
higher
life
elderly
population.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 651 - 651
Published: May 27, 2024
Alzheimer’s
disease
(AD)
is
a
stealthy
and
progressive
neurological
disorder
that
leading
cause
of
dementia
in
the
global
elderly
population,
imposing
significant
burden
on
both
society.
Currently,
condition
treated
with
medications
alleviate
symptoms.
Nonetheless,
these
drugs
may
not
consistently
produce
desired
results
can
serious
side
effects.
Hence,
there
vigorous
pursuit
alternative
options
to
enhance
quality
life
for
patients.
Ginkgo
biloba
(GB),
an
herb
historical
use
traditional
medicine,
contains
bioactive
compounds
such
as
terpenoids
(Ginkgolides
A,
B,
C),
polyphenols,
organic
acids,
flavonoids
(quercetin,
kaempferol,
isorhamnetin).
These
are
associated
anti-inflammatory,
antioxidant,
neuroprotective
properties,
making
them
valuable
cognitive
health.
A
systematic
search
across
three
databases
using
specific
keywords—GB
AD
dementia—yielded
1702
documents,
selection
15
clinical
trials
synthesis.
In
eleven
studies,
GB
extract/EGb
761®
was
shown
improve
function,
neuropsychiatric
symptoms,
functional
abilities
types.
four
however,
were
no
differences
between
GB-treated
placebo
groups.
Significant
improvements
observed
scores
obtained
from
Mini-Mental
State
Examination
(MMSE),
Short
Cognitive
Performance
Test
(SKT),
Neuropsychiatric
Inventory
(NPI).
While
majority
synthesized
show
has
promising
potential
treatment
conditions,
more
research
needed
determine
optimal
dosages,
effective
delivery
methods,
appropriate
pharmaceutical
formulations.
Furthermore,
thorough
assessment
adverse
effects,
exploration
long-term
implications,
investigation
into
drug
interactions
critical
aspects
must
be
carefully
evaluated
future
studies.
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin's
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2,256
documents,
leading
selection
15
clinical
trials
synthesis.
Here
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2721 - 2721
Published: Aug. 15, 2024
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin’s
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2256
documents,
leading
selection
15
clinical
trials
synthesis.
Here,
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2096 - 2096
Published: Sept. 13, 2024
The
triad
of
vascular
impairment,
muscle
atrophy,
and
cognitive
decline
represents
critical
age-related
conditions
that
significantly
impact
health.
Vascular
impairment
disrupts
blood
flow,
precipitating
the
mass
reduction
seen
in
sarcopenia
neuronal
function
characteristic
neurodegeneration.
Our
limited
understanding
intricate
relationships
within
this
hinders
accurate
diagnosis
effective
treatment
strategies.
This
review
analyzes
interrelated
mechanisms
contribute
to
these
conditions,
with
a
specific
focus
on
oxidative
stress,
chronic
inflammation,
impaired
nutrient
delivery.
aim
is
understand
common
pathways
involved
suggest
comprehensive
therapeutic
approaches.
dysfunctions
hinder
circulation
transportation
nutrients,
resulting
characterized
by
atrophy
weakness.
dysfunction
have
negative
physical
quality
life.
Neurodegenerative
diseases
exhibit
comparable
pathophysiological
affect
motor
functions.
Preventive
approaches
encompass
lifestyle
adjustments,
addressing
integrated
therapies
improving
muscular
well-being.
Better
links
can
refine
strategies
yield
better
patient
outcomes.
study
emphasizes
complex
interplay
between
dysfunction,
degeneration,
decline,
highlighting
necessity
for
multidisciplinary
Advances
domain
promise
improved
diagnostic
accuracy,
more
options,
enhanced
preventive
measures,
all
contributing
higher
life
elderly
population.
