Published: March 5, 2024
Intrahepatic cholangiocarcinoma (ICCA) is a malignant epithelial neoplasm characterized by biliary differentiation within the liver. ICCA molecularly heterogeneous and exhibits broad spectrum of histopathological features. It highly aggressive carcinoma with high mortality poor survival rates. ICCAs are classified into two main subtypes: small duct type large types. These tumor types have different cell origins clinicopathological numerous molecular alterations, including mutations in KRAS, TP53, IDH1/2, ARID1A, BAP1, BRAF, SAMD4, EGFR, FGFR2 fusion. Two subtypes–inflammation proliferation–have been proposed. Recent advances high-throughput assays using next-generation sequencing improved our understanding pathogenesis genetics. The diagnosis poses significant challenge for pathologists because its varied morphologies phenotypes. Accurate essential effective patient management prognostic determination. This article provides an updated overview pathology, focusing particularly on features, histological subtypes, diagnostic approaches.
Language: Английский