Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver DOI Creative Commons
Giovanni Colonna

Livers, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 31, 2024

Background: This study addresses a particular aspect of the biological behavior Spike subunit S1 SARS-CoV-2. Researchers observed acting freely in human organism during and after COVID-19 vaccination. One its properties is that it interacts one-to-one with proteins. 12 specific proteins liver. Methods: We used these as seeds to extract their functional relationships from proteome through enrichment. The interactome representing set metabolic activities which they are involved shows several molecular processes (KEGG), including some linked HBV (hepatitis B) HCC (hepatocellular carcinoma) many genes/proteins involved. Reports show that, COVID patients, reactivated or progressed cancer. Results: analyzed approaches understand whether two pathologies have independent progressions common progression. All our efforts consistently showed involving both significantly present all we used, making difficult any useful information about fate. Through BioGRID, extracted experimental data vivo but derived model cell systems. lack patient STRING results prevents diagnosis prediction real disease progression; therefore, can consider them “aseptic” data. Conclusion: tells us genes HVB-related pathways potential activate processes. gold standard. It comparison similar interactions found individual phenotypes phenotype favors hinders also suggests how use features. These sets constitute “toolkit”. In fact, if compare patient, will provide on level phenotypic state driving disease. composition an entire group broader more detailed than single marker. Therefore, protein compositions serve reference system doctors cases for personalized medicine diagnoses.

Language: Английский

A tiny viral protein, SARS-CoV-2-ORF7b: Functional molecular mechanisms. DOI Open Access
Gelsomina Mansueto, Giovanna Fusco, Giovanni Colonna

et al.

Published: March 8, 2024

This study presents the interaction with human host metabolism of SARS-CoV-2 ORF7b protein (43 aa), using a Protein-Protein-Interaction Networks analysis. After pruning, we selected from BioGRID 51 most significant proteins among 2,753 proven interactions and 1,708 interactors, specific to ORF7b. We used these as functional seeds got network 551 nodes via STRING. performed topological analysis calculated distributions by Cytoscape. Seven high ranked hub seven bottleneck following hub-and-spoke network-architectural-model were found. Through this model, identified GO-processes (5,057 terms in 15 categories) induced High statistical significance processes dysregulated molecular cell mechanisms action discovered. detected disease-related their involvement metabolic roles, how they relate distorted way signaling and/or systems, particular intra- inter-cellular systems that supervise programmed death, similar cancer metastasis diffusion. A cluster showed 10 compact clusters, where two them overlap Giant-Connected-Components core 206 total nodes. These clusters contain high-rank mainly acts through inducing dysregulation. conducted co-regulation, transcriptional proteins. allowed us define transcription factors miRNAs control high-ranking processes, within limits poor knowledge sectors still impose.

Language: Английский

Citations

2
Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver DOI Creative Commons
Giovanni Colonna

Livers, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 31, 2024

Background: This study addresses a particular aspect of the biological behavior Spike subunit S1 SARS-CoV-2. Researchers observed acting freely in human organism during and after COVID-19 vaccination. One its properties is that it interacts one-to-one with proteins. 12 specific proteins liver. Methods: We used these as seeds to extract their functional relationships from proteome through enrichment. The interactome representing set metabolic activities which they are involved shows several molecular processes (KEGG), including some linked HBV (hepatitis B) HCC (hepatocellular carcinoma) many genes/proteins involved. Reports show that, COVID patients, reactivated or progressed cancer. Results: analyzed approaches understand whether two pathologies have independent progressions common progression. All our efforts consistently showed involving both significantly present all we used, making difficult any useful information about fate. Through BioGRID, extracted experimental data vivo but derived model cell systems. lack patient STRING results prevents diagnosis prediction real disease progression; therefore, can consider them “aseptic” data. Conclusion: tells us genes HVB-related pathways potential activate processes. gold standard. It comparison similar interactions found individual phenotypes phenotype favors hinders also suggests how use features. These sets constitute “toolkit”. In fact, if compare patient, will provide on level phenotypic state driving disease. composition an entire group broader more detailed than single marker. Therefore, protein compositions serve reference system doctors cases for personalized medicine diagnoses.

Language: Английский

Citations

0