Published: March 11, 2024
Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack synthesis FMR protein (FMRP) are associated with syndrome, which is one most prevalent inherited intellectual disabilities. FMRP a multifunctional involved in many cellular functions nearly all subcellular compartments under normal conditions stress both neuronal non-neuronal cell types. This achieved through its trafficking signals, nuclear localization signal (NLS), export (NES), nucleolar (NoLS), as well RNA binding domains, modulated by various post-translational modifications such phosphorylation, ubiquitination, sumoylation, methylation. review summarizes recent advances understanding interaction networks special focus on stress-related functions, including granule formation, mitochondrion endoplasmic reticulum plasticity, ribosome biogenesis, cycle control, DNA damage response.
Language: Английский