Investigation of Anti-Cancer Properties of Novel Curcuminoids in Leukemic Cells and Dalton Lymphoma Ascites Model DOI Open Access
V. Sudarshan,

P. Shyamjith,

Sujeet Kumar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3186 - 3186

Published: March 29, 2025

Leukemia, one of the major causes cancer death, ranks 11th worldwide among cancer-related deaths. The current treatment leukemia faces challenges recently due to a high burden side effects. It is well established that curcumin has anticancer and tumor-suppressing activities in several cancers addition leukemia. Accordingly, 15 derivatives were designed prepared improve shortcomings curcumin, such as poor aqueous solubility, chemical instability, low bioavailability. All evaluated for cytotoxicity against leukemic cell line MOLT-4, which led prioritization further evaluation compound curcuminoid (2E,5E)-2,5-bis((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)cyclopentan-1-one 5i. Compared 5i was significantly more effective inducing mitochondrial dysfunction MOLT-4 cells; hence increased ROS production cytotoxicity. Treatment groups showed change membrane potential by flow cytometry analysis. Moreover, tumor volume reduction observed with Dalton’s Lymphoma model accompanied toxicity. Intrinsic pathways apoptosis initiated lowered Bcl-2 expression while augmenting cytochrome c, Bak Bax levels both vivo vitro. These results showcase potent antiproliferative cytotoxic effects at nanomolar doses being least 60 times than curcumin.

Language: Английский

Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis DOI Open Access
Ștefan Horia Roșian,

Ioana Boarescu,

Paul-Mihai Boarescu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1379 - 1379

Published: Feb. 6, 2025

Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains leading cause cardiovascular morbidity mortality worldwide. Oxidative stress inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, plaque instability. Emerging evidence highlights potential bioactive compounds with antioxidant anti-inflammatory properties mitigate these processes promote vascular health. This review explores mechanisms through which compounds-such as polyphenols, carotenoids, flavonoids, omega-3 fatty acids, coenzyme Q10, other natural compounds-modulate oxidative in atherosclerosis. It examines their effects on key molecular pathways, including inhibition reactive oxygen species (ROS) production, suppression nuclear factor-κB (NF-κB), modulation cytokines. By integrating current knowledge, this underscores therapeutic dietary supplemental complementary strategies for managing atherosclerosis, paving way future research clinical applications.

Language: Английский

Citations

6
The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders DOI Creative Commons

Tadahiro Numakawa,

Ryutaro Kajihara

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 848 - 848

Published: Feb. 12, 2025

Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival synaptic regulation the central nervous system's (CNS's) neurons. binds to TrkB (a tyrosine kinase) with high affinity, resulting downstream intracellular signaling cascades play crucial roles determining fate, neuronal differentiation maturation of CNS It well demonstrated that downregulation/dysregulation BDNF/TrkB system is implicated pathogenesis neurologic psychiatric disorders, such as Alzheimer's disease (AD) depression. Interestingly, effects mimetic compounds flavonoids, small molecules which can activate TrkB-mediated signaling, have investigated potential therapeutic strategies brain diseases, given p75NTR, a common neurotrophin receptor, also contributes death under variety pathological conditions neurodegeneration. Since downregulation associated pathophysiology neurodegenerative diseases understanding how alterations contribute progression could provide valuable insight prevention these diseases. The present review shows recent advances molecular mechanisms underlying plasticity, providing critical insights into impact mimetics

Language: Английский

Citations

4
A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-inflammatory and Anticancer Activities DOI Open Access
Kirandeep Kaur, Ahmad K. Al-Khazaleh, Deep Jyoti Bhuyan

et al.

Published: March 21, 2024

Curcumin, as the main active component of Turmeric (Curcuma Longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such poor solubility and bioavailability, rapid metabolism, pan-assay interference properties. Recent advancements have aimed to overcome these limitations developing novel curcumin analogues modifications. This brief review critically assesses recent studies on synthesising different analogues, including metal complexes, nano particulates, other derivatives, focused antioxidant, anti-inflammatory, anticancer effects modified analogues. Exploring innovative derivatives offers promising strategies address associated bioavailability efficacy valuable insights for future research directions.

Language: Английский

Citations

6
Potential of Curcumin and Its Analogs in Glioblastoma Therapy DOI Creative Commons
Agnieszka Nowacka, Ewa Ziółkowska, Wojciech Smuczyński

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 351 - 351

Published: March 18, 2025

Curcumin, a polyphenol found in turmeric, demonstrates multifaceted anti-cancer activity against glioblastoma. Its therapeutic potential stems from its ability to modulate various molecular pathways implicated glioblastoma development and progression, enhance the effectiveness of radiation therapy, induce cancer cell death through diverse mechanisms, including apoptosis, autophagy, cycle arrest. These combined actions make curcumin promising candidate for treatment, warranting further investigation into clinical application. In this review, we summarize latest research on analogs' therapy.

Language: Английский

Citations

0
Updated Review on Natural Polyphenols: Molecular Mechanisms, Biological Effects, and Clinical Applications for Cancer Management DOI Creative Commons
Zainab Sabry Othman Ahmed, Elyas Khan, Nahel Elias

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 629 - 629

Published: April 28, 2025

Polyphenols, naturally occurring compounds found exclusively in plants, have gained significant attention for their potential cancer prevention and treatment. These are known antioxidant properties abundant various plant-based foods, such as vegetables, fruits, grains, beverages. Recent studies highlighted the broad spectrum of health benefits polyphenols, including antiviral, anti-inflammatory, anticancer properties. In addition, these derived increasingly important drug discovery due to high molecular diversity novel biofunctionalities. This review provides an in-depth analysis current research knowledge on use dietary polyphenols bioactive treatment cancers. aims provide valuable insights into mechanisms underlying phenolic both laboratory clinical settings. Furthermore, this highlights positive outcomes associated with agents offers guidance future advance promising field.

Language: Английский

Citations

0
Investigation of Anti-Cancer Properties of Novel Curcuminoids in Leukemic Cells and Dalton Lymphoma Ascites Model DOI Open Access
V. Sudarshan,

P. Shyamjith,

Sujeet Kumar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3186 - 3186

Published: March 29, 2025

Leukemia, one of the major causes cancer death, ranks 11th worldwide among cancer-related deaths. The current treatment leukemia faces challenges recently due to a high burden side effects. It is well established that curcumin has anticancer and tumor-suppressing activities in several cancers addition leukemia. Accordingly, 15 derivatives were designed prepared improve shortcomings curcumin, such as poor aqueous solubility, chemical instability, low bioavailability. All evaluated for cytotoxicity against leukemic cell line MOLT-4, which led prioritization further evaluation compound curcuminoid (2E,5E)-2,5-bis((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)cyclopentan-1-one 5i. Compared 5i was significantly more effective inducing mitochondrial dysfunction MOLT-4 cells; hence increased ROS production cytotoxicity. Treatment groups showed change membrane potential by flow cytometry analysis. Moreover, tumor volume reduction observed with Dalton’s Lymphoma model accompanied toxicity. Intrinsic pathways apoptosis initiated lowered Bcl-2 expression while augmenting cytochrome c, Bak Bax levels both vivo vitro. These results showcase potent antiproliferative cytotoxic effects at nanomolar doses being least 60 times than curcumin.

Language: Английский

Citations

0