Exploring Asthma as a Protective Factor in COVID-19 Outcomes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1678 - 1678

Published: Feb. 16, 2025

Asthma has long been associated with increased susceptibility to viral respiratory infections, leading significant exacerbations and poorer clinical outcomes. Contrarily interestingly, emerging data research surrounding the COVID-19 pandemic have shown that patients asthma infected SARS-CoV-2 experienced decreased severity of disease, lower hospitalization rates, as well morbidity mortality. Research eosinophils could enhance immune defense against while inhaled corticosteroids can assist in controlling systematic inflammation. Moreover, reduced ACE-2 expression individuals may restrict entry, Th2 response offset Th1 typically observed severe patients. These factors help explain favorable outcomes seen asthmatic during pandemic. This review highlights potential protective mechanisms patients, including eosinophilia, use corticosteroids, expression, a dominate response. Such study will be helpful better manage who contracted COVID-19.

Language: Английский

The Correlation between Cardiac Magnetic Resonance Findings and Post-COVID-19: The Impact of Myocardial Injury on Quality of Life

Diagnostics, Journal Year: 2024, Volume and Issue: 14(17), P. 1937 - 1937

Published: Sept. 2, 2024

Background: In the post-COVID-19 era, there is growing concern regarding its impact on cardiovascular health and following effects overall quality of life affected individuals. This research seeks to investigate cardiac magnetic resonance (CMR) findings COVID-19 their Methods: An observational, cross-sectional study was conducted in consecutive patients with persistent symptoms after who were referred CMR due suspected myocardial injury. addition, completed a questionnaire about during period. Results: this study, 85 included. The population consisted mean age 42.5 ± 13.4 years, predominantly women, made up 69.4% population, while men 30.6%. showed non-ischemic injury 78.8% edema 14.1% patients. Late pericardial enhancement present 40% effusion 51.8% Pericardial (p = 0.001) more prevalent reported pronounced period compared acute infection phase. Predictors lower presence irregular heartbeat 0.039), problems that last longer than 12 weeks 0.018), 0.037). Conclusion: Acute myocarditis observed minority COVID-19, LGE pattern majority. Quality worse abnormalities, primarily effusion. Also, heartbeat, weeks, as well independent predictors

Language: Английский

A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto’s Thyroiditis: Analysis of Asthenia as Admission Complaint

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1380 - 1380

Published: Oct. 27, 2024

Background: Amid the large panel of autoimmune thyroid diseases, Hashimoto’s thyroiditis (HT) represents a major point across multidisciplinary daily practice. When it comes to clinical picture, particularly in regard asthenia (also described as “fatigue” or “decreased energy”), differential diagnosis is challenging, and meticulous anamnesis should be backed up by focused lab investigations. Our objective was analyze newly diagnosed patients with HT relationship presence an admission complaint. Methods: This retrospective, multi-centric, real-life study conducted secondary endocrine units (university hospitals) from July 2022 2023. The exclusion criteria were COVID-19 infection; active malignancy, etc. Results: cohort (N = 120) included group (AS, 49.2%) non-AS similar age (49.3 ± 14.7 vs. 47.1 14.8 y, p 0.426). Headache more frequent AS (35.6% 18%, 0.03). Thyroid function HT-related antibodies assays between groups show no correlation serum total cholesterol triglycerides, respectively. TSH levels did not vary among sub-groups (p 0.701). One third studied population affected hypothyroidism (TSH > 4.5 μIU/mL), being seen at higher rate (39%) (23%). Total positively correlated patients’ (r 0.180, 0.049) triglycerides 120; r 0.324, < 0.001), found only 0.246, 0.006, respectively, 0.319, 0.001). Conclusions: analysis pinpointed fact that, practice, complaint seems less indicator underlying dysfunction level against without full picture thyrotoxicosis myxoedema.

Language: Английский