A Survey on Computational Methods in Drug Discovery for Neurodegenerative Diseases
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1330 - 1330
Published: Oct. 19, 2024
Currently,
the
age
structure
of
world
population
is
changing
due
to
declining
birth
rates
and
increasing
life
expectancy.
As
a
result,
physicians
worldwide
have
treat
an
number
age-related
diseases,
which
neurological
disorders
represent
significant
part.
In
this
context,
there
urgent
need
discover
new
therapeutic
approaches
counteract
effects
neurodegeneration
on
human
health,
computational
science
can
be
pivotal
importance
for
more
effective
neurodrug
discovery.
The
knowledge
molecular
receptors
other
biomolecules
involved
in
pathogenesis
facilitates
design
molecules
as
potential
drugs
used
fight
against
diseases
high
social
relevance
such
dementia,
Alzheimer's
disease
(AD)
Parkinson's
(PD),
cite
only
few.
However,
absence
comprehensive
guidelines
regarding
strengths
weaknesses
alternative
creates
fragmented
disconnected
field,
resulting
missed
opportunities
enhance
performance
achieve
successful
applications.
This
review
aims
summarize
some
most
innovative
strategies
based
methods
development.
particular,
recent
applications
state-of-the-art
docking
artificial
intelligence
ligand-
target-based
novel
drug
were
reviewed,
highlighting
crucial
role
silico
context
discovery
neurodegenerative
diseases.
Language: Английский
Drug Development for Alzheimer’s and Parkinson’s Disease: Where Do We Go Now?
Published: April 5, 2024
Neurodegenerative
diseases
(NDs)
are
a
set
of
progressive,
chronic,
and
incurable
characterized
by
the
gradual
loss
neurons,
culminating
in
decline
cognitive
and/or
motor
functions.
Alzheimer’s
disease
(AD)
Parkinson’s
(PD)
most
common
NDs
represent
an
enormous
burden
both
terms
human
suffering
economic
cost.
The
available
therapies
for
AD
PD
only
provide
symptomatic
palliative
relief
limited
period
unable
to
modify
diseases’
progression.
Over
last
decades,
research
efforts
have
been
focused
on
developing
new
pharmacological
treatments
these
NDs.
However,
date,
no
breakthrough
treatment
has
discovered.
Hence,
development
disease-modifying
drugs
able
halt
or
reverse
progression
remains
unmet
clinical
need.
This
review
summarizes
major
hallmarks
treatment.
It
also
sheds
light
potential
directions
that
can
be
pursued
develop
new,
treat
PD,
thereby
decreasing
social
burdens
linked
Language: Английский
Aquilaria crassna Extract Exerts Neuroprotective Effect against Benzo[a]pyrene-Induced Toxicity in Human SH-SY5Y Cells: An RNA-Seq-Based Transcriptome Analysis
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2727 - 2727
Published: Aug. 16, 2024
Benzo[a]pyrene
(B[a]P)
is
known
to
inhibit
neurodifferentiation
and
induce
neurodegeneration.
Agarwood
or
Aquilaria
crassna
(AC),
a
plant
with
health-promoting
properties,
may
counteract
the
neurotoxic
effects
of
B[a]P
by
promoting
neuronal
growth
survival.
This
study
investigated
protective
effect
AC
leaf
ethanolic
extract
(ACEE)
on
B[a]P-induced
impairment
differentiation.
A
transcriptomic
analysis
identified
canonical
pathway,
biological
network,
differentially
expressed
genes
(DEGs)
that
are
changed
in
response
differentiation
neurogenesis.
Several
genes,
including
CXCR4,
ENPP2,
GAP43,
GFRA2,
NELL2,
NFASC,
NSG2,
NGB,
BASP1,
NEUROD1,
B[a]P-treated
SH-SY5Y
cells
were
up-regulated
after
treatment
ACEE.
Notably,
Western
blot
further
confirmed
ACEE
increased
protein
levels
GAP43
neuroglobin.
led
decreased
phosphorylation
Akt
ERK
cells;
however,
was
able
reverse
these
effects.
Clionasterol
lupenone
Molecular
docking
showed
two
phytochemicals
had
significant
interactions
GDNF
family
receptor
alpha
(GFRA),
retinoid
X
receptors
(RXRs).
In
conclusion,
be
potential
alternative
medicine
for
prevention
impaired
neurodegenerative
diseases.
Language: Английский