Optimization of a Pressurized Extraction Process Based on a Ternary Solvent System for the Recovery of Neuroprotective Compounds from Eucalyptus marginata Leaves DOI Open Access
Soumaya Hasni, Hajer Riguene, J. A. Mendiola

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 94 - 94

Published: Dec. 26, 2024

Green chemistry focuses on reducing the environmental impacts of chemicals through sustainable practices. Traditional methods for extracting bioactive compounds from Eucalyptus marginata leaves, such as hydro-distillation and organic solvent extraction, have limitations, including long extraction times, high energy consumption, potential toxic residues. This study explored use supercritical fluid (SFE), pressurized liquid (PLE), gas-expanded (GXL) processes to improve efficiency selectivity. These techniques were combined in a single mixture design, where CO2 was used experiments carried out under SFE, while water ethanol PLE GXL by varying concentration solvents cover all possibilities. The neuroprotective activity extracts evaluated measuring their antioxidant, anti-inflammatory, acetylcholinesterase inhibition properties. optimization resulted novel with an optimal ternary 27% CO2, 55% ethanol, 18% water, degree desirability (R2 = 88.59%). Chromatographic analysis GC-MS HPLC-ESI-MS/MS identified over 49 metabolites. designed process offers promising approach producing phenolic-rich plant industrial applications.

Language: Английский

The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports DOI Open Access
Ana C. Gonçalves, S. Sofia M. Rodrigues,

Rafael Rodrigues

et al.

Published: April 8, 2024

Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental compo-nents. Globally, in 2019, 18 million people had RA. RA characterised by persistent inflammation of the synovial membrane that lines joints, cartilage loss, bone erosion. Phenolic molecules are most prevalent secondary metabolites plants, diverse spectrum biological ac-tions benefit functional meals nutraceuticals. These compounds have received lot at-tention recently because they antioxidant, anti-inflammatory, immunomodulatory, anti-rheumatoid activity modulating tumour necrosis factor, mitogen-activated protein kinase, nu-clear factor kappa-light-chain-enhancer activated B cells, c-Jun N-terminal kinases, as well other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, innovative delivery technologies for treatment RA, focus on possible activities. Nonetheless, commercialization polyphenols may be achievable only after confirming safety profile completing successful clinical trials.

Language: Английский

Citations

5
Study on effects of Bamboo Rice on Experimentally induced Rheumatoid Arthritis in Wistar Rats DOI

Julia Sebastián,

Kalpuri Subhash,

Pradeep B. Patil

et al.

Food and Humanity, Journal Year: 2025, Volume and Issue: unknown, P. 100604 - 100604

Published: April 1, 2025

Language: Английский

Citations

0
Prospecting Pharmacologically Active Biocompounds from the Amazon Rainforest: In Vitro Approaches, Mechanisms of Action Based on Chemical Structure, and Perspectives on Human Therapeutic Use DOI Creative Commons
Andryo Orfi Almada-Vilhena, Oscar Vinícius Moraes dos Santos, Milla de Andrade Machado

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1449 - 1449

Published: Oct. 30, 2024

The Amazon rainforest is an important reservoir of biodiversity, offering vast potential for the discovery new bioactive compounds from plants. In vitro studies allow investigation biological processes and interventions in a controlled manner, making them fundamental pharmacological biotechnological research. These approaches are faster less costly than vivo studies, providing standardized conditions that enhance reproducibility precision data. However, methods have limitations, including inability to fully replicate complexity living organism absence complete physiological context. Translating results models not always straightforward, due differences pharmacokinetics interactions. this context, aim literature review assess advantages disadvantages search drugs Amazon, identifying challenges limitations associated with these comparing testing. Thus, bioprospecting involves evaluating plant extracts through bioassays investigate pharmacological, antimicrobial, anticancer activities. Phenolic terpenes frequently identified as main agents, exhibiting antioxidant, anti-inflammatory, antineoplastic Chemical characterization, molecular modifications, development delivery systems, such nanoparticles, highlighted improve therapeutic efficacy. Therefore, offers great drugs; however, significant challenges, standardization extraction need clinical trials, must be overcome become viable medications.

Language: Английский

Citations

1
Hesperetin: A Potent Phytochemical Constituent for the Treatment of Rheumatoid Arthritis DOI

Tasawar Iqbal,

Sidra Altaf,

Iman Basit

et al.

Pakistan BioMedical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 02 - 10

Published: Aug. 31, 2024

Hesperetin, a flavonoid abundant in citrus fruits and various vegetables, has emerged as promising phytochemical for the treatment of rheumatoid arthritis (RA). With its strong anti-inflammatory antioxidant properties, hesperidin offers multifaceted approach to reducing symptoms progression arthritis. The pathogenesis RA involves complex interplay between inflammatory cytokines, immune dysregulation, oxidative stress. Hesperidin exerts therapeutic effects by modulating these pathways. This drug prevents production pro-inflammatory cytokines such tumor necrosis factor-α, interleukin-6, interleukin-1β, thus inflammation joint damage. shows immunomodulatory function cells. It inhibits activity cells macrophages neutrophils, which play an important role development In addition, hesperetin activation nuclear factor κB, transcription involved expression genes, exhibits broad effects. Hesperetin supplementation improves clinical markers patients with is natural compound obtained from food sources fewer side than traditional drugs, making it attractive alternative or complementary treatment. Hespertin Its pleiotropic mechanisms action, including anti-inflammatory, effects, have great potential reduce arthritis, stop disease improve quality life patients. review article highlights trials needed fully elucidate benefits determine conventional

Language: Английский

Citations

0
Optimization of a Pressurized Extraction Process Based on a Ternary Solvent System for the Recovery of Neuroprotective Compounds from Eucalyptus marginata Leaves DOI Open Access
Soumaya Hasni, Hajer Riguene, J. A. Mendiola

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 94 - 94

Published: Dec. 26, 2024

Green chemistry focuses on reducing the environmental impacts of chemicals through sustainable practices. Traditional methods for extracting bioactive compounds from Eucalyptus marginata leaves, such as hydro-distillation and organic solvent extraction, have limitations, including long extraction times, high energy consumption, potential toxic residues. This study explored use supercritical fluid (SFE), pressurized liquid (PLE), gas-expanded (GXL) processes to improve efficiency selectivity. These techniques were combined in a single mixture design, where CO2 was used experiments carried out under SFE, while water ethanol PLE GXL by varying concentration solvents cover all possibilities. The neuroprotective activity extracts evaluated measuring their antioxidant, anti-inflammatory, acetylcholinesterase inhibition properties. optimization resulted novel with an optimal ternary 27% CO2, 55% ethanol, 18% water, degree desirability (R2 = 88.59%). Chromatographic analysis GC-MS HPLC-ESI-MS/MS identified over 49 metabolites. designed process offers promising approach producing phenolic-rich plant industrial applications.

Language: Английский

Citations

0