Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study DOI Open Access
N. Stepanova, L. Korol,

Tetyana Ostapenko

et al.

Published: April 16, 2024

Background: Nutritional status and oxidative stress have been implicated in the pathogenesis persistence of long COVID, but data patients undergoing hemodialysis (HD) are limited. The present study aimed to investigate association between pre-infection nutritional status, stress, one-year COVID HD patients. Methods: This prospective observational cohort enrolled 115 with confirmed COVID-19. was assessed using Controlling Status (CONUT) score twice: before infection three months post-infection. Oxidative markers included malondialdehyde (MDAs), ceruloplasmin, transferrin, sulfhydryl groups. endpoint persistence. Results: Moderate CONUT scores were associated heightened severe undernutrition risk (p < 0.0001), elevated MDAs reduced ceruloplasmin levels = 0.0009) at post-COVID-19 compared light scores. Pre-infection independently predicted post-COVID damage [OR 2.3 (95%CI 1.2; 4.6), p 0.0001] [HR 4.6 1.4; 9.9), 0.0001], even after adjusting for potential confounders. Conclusion: increased intensity

Language: Английский

Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study DOI Open Access
N. Stepanova, L. Korol,

Tetyana Ostapenko

et al.

Published: April 16, 2024

Background: Nutritional status and oxidative stress have been implicated in the pathogenesis persistence of long COVID, but data patients undergoing hemodialysis (HD) are limited. The present study aimed to investigate association between pre-infection nutritional status, stress, one-year COVID HD patients. Methods: This prospective observational cohort enrolled 115 with confirmed COVID-19. was assessed using Controlling Status (CONUT) score twice: before infection three months post-infection. Oxidative markers included malondialdehyde (MDAs), ceruloplasmin, transferrin, sulfhydryl groups. endpoint persistence. Results: Moderate CONUT scores were associated heightened severe undernutrition risk (p < 0.0001), elevated MDAs reduced ceruloplasmin levels = 0.0009) at post-COVID-19 compared light scores. Pre-infection independently predicted post-COVID damage [OR 2.3 (95%CI 1.2; 4.6), p 0.0001] [HR 4.6 1.4; 9.9), 0.0001], even after adjusting for potential confounders. Conclusion: increased intensity

Language: Английский

Citations

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