Reduction in Hippocampal Aβ Content During Gly-Pro-Glu Co-Administration Is Associated with Changes in Inflammation and IGF-I Signaling DOI Open Access
Laura M. Frago, Emma Burgos‐Ramos, María Rodríguez-Pérez

et al.

Published: April 18, 2024

Alzheimer´s disease (AD) is characterized by the brain deposition of senile plaques composed amyloid-β peptides (Aβ) that increase inflammation. An endogenous peptide derived from insulin-like growth factor (IGF)-I, glycine-proline-glutamate (GPE) has IGF-I-sensitizing and neuroprotective actions. Here, we examined effects GPE on Aβ levels hippocampal inflammation generated intracerebroventricular infusion Aβ25-35 during 2 weeks (300 pmol/day) in ovariectomized rats signaling-related pathways Aβ-degrading enzymes associated with these GPE-related effects. prevented Aβ-induced phosphorylation p38 mitogen-activated protein kinase reduction activation signal transducer activator transcription 3, insulin receptor substrate-1 Akt, as well interleukin (IL)-2 IL-13 hippocampus. The functionality somatostatin, measured percentage inhibition adenylate cyclase activity insulin-degrading enzyme were also preserved co-treatment. These findings indicate co-administration may protect insult changing cytokine content somatostatin through regulation leptin- IGF-I-signaling could influence modulation and/or proteases.

Language: Английский

Reduction in Hippocampal Aβ Content During Gly-Pro-Glu Co-Administration Is Associated with Changes in Inflammation and IGF-I Signaling DOI Open Access
Laura M. Frago, Emma Burgos‐Ramos, María Rodríguez-Pérez

et al.

Published: April 18, 2024

Alzheimer´s disease (AD) is characterized by the brain deposition of senile plaques composed amyloid-β peptides (Aβ) that increase inflammation. An endogenous peptide derived from insulin-like growth factor (IGF)-I, glycine-proline-glutamate (GPE) has IGF-I-sensitizing and neuroprotective actions. Here, we examined effects GPE on Aβ levels hippocampal inflammation generated intracerebroventricular infusion Aβ25-35 during 2 weeks (300 pmol/day) in ovariectomized rats signaling-related pathways Aβ-degrading enzymes associated with these GPE-related effects. prevented Aβ-induced phosphorylation p38 mitogen-activated protein kinase reduction activation signal transducer activator transcription 3, insulin receptor substrate-1 Akt, as well interleukin (IL)-2 IL-13 hippocampus. The functionality somatostatin, measured percentage inhibition adenylate cyclase activity insulin-degrading enzyme were also preserved co-treatment. These findings indicate co-administration may protect insult changing cytokine content somatostatin through regulation leptin- IGF-I-signaling could influence modulation and/or proteases.

Language: Английский

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