Prolonged CBD Pressure Mediates Higher Expression of flgA in <em>Salmonella</em> typhimurium DOI Open Access
Iddrisu Ibrahim,

Alexa Mathias,

D. C. Johnson

et al.

Published: May 29, 2024

Salmonella Typhimurium is a typical Gram-Negative bacterium associated with food-borne illness threatening public health. This pathogen reported to have caused millions of infections and thousands hospitalizations yearly in the United States alone. has sophisticated array virulent factors, including its flagella, which contributes significantly pathogenicity. Cannabidiol (CBD), non-psychoactive component cannabis plant, attracted interest many researchers recently because antimicrobial properties. With growing exploring CBD&rsquo;s properties, we, this study, delved into unravelling how prolonged exposure CBD influences expression flgA gene. We hypothesized that may result upregulation, causing bacteria withstand various stresses potentially enhance survival rates employed several assays, such as mRNA expression, motility pH induction nutrient starvation interventions, biofilm analysis, explore influence on pathophysiology Typhimurium. Our findings reveal CBD-resistant strains exhibit enhanced resilience extreme levels survive poorly under starvation, more robust formation compared susceptible strains. The results contribute broader comprehension resistance mechanisms bacteria. work provides insight potential therapeutic interventions for controlling bacterial infections. study also underscores essence novel alternative agents tackle ever-persistence antibiotic resistance.

Language: Английский

The endocannabinoid system as a therapeutic target in neuropathic pain: a review DOI
Jose-Manuel Quintero, Luis E. Díaz, Ismael Galve‐Roperh

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: 28(9), P. 739 - 755

Published: Sept. 1, 2024

This review highlights the critical role of endocannabinoid system (ECS) in regulating neuropathic pain and explores therapeutic potential cannabinoids. Understanding mechanisms ECS, including its receptors, endogenous ligands, enzymatic routes, can lead to innovative treatments for chronic pain, offering more effective therapies conditions. bridges gap between preclinical studies clinical applications by emphasizing ECS modulation better management outcomes.

Language: Английский

Citations

5
The Interplay between 2-Arachidonoylglycerol and Anandamide Amidohydrolase in Neuropathy DOI Open Access
Iddrisu Ibrahim, Joseph Ayariga,

Junhuan Xu

et al.

Published: May 13, 2024

The endocannabinoid system (ECS) is a complex neuromodulatory network in the human body that have enormous impact developing central nervous system, as well modulates various physiological processes. ECS made up of anandamide, 2-arachidonoylglycerol (2-AG), which are responsible for synthesis and degradation endocannabinoids, enzymes such FAAH MAGL ensures precise control over levels. relies on CB1 receptors found (CNS), CB2 peripheral immune cells. Dysregulation has been associated with several health conditions, prompting investigations into its association phytocannabinoids to harness their therapeutic potential. intricately linked it known modulate neuronal activities CNS, influencing pain mood modulation. also neuropathies-peripheral nerve damage leading symptoms weakness, numbness evidenced diabetic neuropathy, Guillain-Barr&eacute; Syndrome, carpal tunnel syndrome, postherpetic neuralgia. focus this review interplay between anandamide amidohydrolase elucidating roles regulation, inflammation, specific neuropathies. knowledge generated expected broad implications, providing comprehensive insights neuropathic conditions how improve them. Ultimately, understanding may lead more effective treatments improved quality life individuals affected by these conditions.

Language: Английский

Citations

3
Prolonged CBD Pressure Mediates Higher Expression of flgA in <em>Salmonella</em> typhimurium DOI Open Access
Iddrisu Ibrahim,

Alexa Mathias,

D. C. Johnson

et al.

Published: May 29, 2024

Salmonella Typhimurium is a typical Gram-Negative bacterium associated with food-borne illness threatening public health. This pathogen reported to have caused millions of infections and thousands hospitalizations yearly in the United States alone. has sophisticated array virulent factors, including its flagella, which contributes significantly pathogenicity. Cannabidiol (CBD), non-psychoactive component cannabis plant, attracted interest many researchers recently because antimicrobial properties. With growing exploring CBD&rsquo;s properties, we, this study, delved into unravelling how prolonged exposure CBD influences expression flgA gene. We hypothesized that may result upregulation, causing bacteria withstand various stresses potentially enhance survival rates employed several assays, such as mRNA expression, motility pH induction nutrient starvation interventions, biofilm analysis, explore influence on pathophysiology Typhimurium. Our findings reveal CBD-resistant strains exhibit enhanced resilience extreme levels survive poorly under starvation, more robust formation compared susceptible strains. The results contribute broader comprehension resistance mechanisms bacteria. work provides insight potential therapeutic interventions for controlling bacterial infections. study also underscores essence novel alternative agents tackle ever-persistence antibiotic resistance.

Language: Английский

Citations

1