Published: May 14, 2024

Cisplatin is an election chemotherapeutic agent for many cancer treatments. Its cytotoxicity against neoplastic cells mirrored by that taking place in healthy and tissues, resulting serious adverse events. A very frequent one ototoxicity, causing hearing loss which may permanently affect quality of life after successful oncologic Exacerbated oxidative stress a main cytotoxic mechanism cisplatin, including ototoxicity. Previous reports have shown antioxidant protection cisplatin but there lack comparative studies on the otoprotectant activity formulations. In this paper we report combination vitamins A, C, E Mg++ (ACEMg), previously to protect noise-induced loss, reverses auditory threshold shifts, promotes outer hair cell survival, attenuates cochlea treatment, thus protecting extreme ototoxicity rat. The addition 500 mg N-acetylcysteine (NAC), administered individually also shows significant attenuation ACEMg formulation, results degradation otoprotection. alone, as MgSO4, prevents with NAC, otoprotection greatly degraded. Increasing dose NAC 1000 mg, dramatic compared NAC. These findings support single antioxidants or combinations, particularly experimental series, efficacy However, excess combined and/or elevated doses, above yet be defined “antioxidation threshold”, unrecoverable redox imbalance activity.

Language: Английский