Expedient Syntheses of Alkyl and Aryl Thioethers using Xanthates as Thiol-Free Reagents DOI Open Access

Jinli Nie,

Ziqing He,

Sijie Xie

et al.

Published: May 15, 2024

Thioethers are critical in the fields of pharmaceuticals and organic synthesis, but most methods for synthesizing alkyl thioethers employ foul-smelling thiols as starting materials or generate them by-products. Additionally, air-sensitive easily oxidized to produce disulfides under atmospheric conditions; thus, a novel method is necessary. This paper reports simple, effective, green dialkyl aryl thioether derivatives using odorless, stable, low-cost ROCS2K thiol surrogate. transformation offers broad substrate scope good functional group tolerance with excellent selectivity. The reaction likely proceeds via xanthate intermediates, which can be readily generated nucleophilic substitution halides transition-metal-free base-free conditions.

Language: Английский

Expedient Syntheses of Alkyl and Aryl Thioethers using Xanthates as Thiol-Free Reagents DOI Open Access

Jinli Nie,

Ziqing He,

Sijie Xie

et al.

Published: May 15, 2024

Thioethers are critical in the fields of pharmaceuticals and organic synthesis, but most methods for synthesizing alkyl thioethers employ foul-smelling thiols as starting materials or generate them by-products. Additionally, air-sensitive easily oxidized to produce disulfides under atmospheric conditions; thus, a novel method is necessary. This paper reports simple, effective, green dialkyl aryl thioether derivatives using odorless, stable, low-cost ROCS2K thiol surrogate. transformation offers broad substrate scope good functional group tolerance with excellent selectivity. The reaction likely proceeds via xanthate intermediates, which can be readily generated nucleophilic substitution halides transition-metal-free base-free conditions.

Language: Английский

Citations

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