Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime-Avibactam in an ST11 Klebsiella Pneumoniae Strain DOI Open Access

Yanqiao Gong,

Yu Feng, Xiaoju Lv

et al.

Published: May 17, 2024

This study describes KPC-204, a novel variant of Klebsiella Pneumoniae carbapenemase, characterized by KDD amino acid insertion at Ambler position 269 deviates from KPC-2. was identified in an ST11-type clinical isolate carbapenem-resistant China. Notably, KPC-204 exhibits resistance to both ceftazidime-avibactam and carbapenems. Genetic analysis revealed that blaKPC-204 located on highly mobile IncFII/IncR plasmid within complex genetic structure facilitates its spread. Functional analysis, achieved through cloning into E. coli DH5α, validates KPC-204's contribution increased ceftazidime-avibactam. The kinetic parameters showed exhibited similar affinity KPC-2 toward ceftazidime reduced sensitivity avibactam. Mating experiments demonstrated the resistance's transmissibility. investigation underscores evolving diversity KPC variants affecting resistance, highlighting necessity for continuous monitoring.

Language: Английский

Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime-Avibactam in an ST11 Klebsiella Pneumoniae Strain DOI Open Access

Yanqiao Gong,

Yu Feng, Xiaoju Lv

et al.

Published: May 17, 2024

This study describes KPC-204, a novel variant of Klebsiella Pneumoniae carbapenemase, characterized by KDD amino acid insertion at Ambler position 269 deviates from KPC-2. was identified in an ST11-type clinical isolate carbapenem-resistant China. Notably, KPC-204 exhibits resistance to both ceftazidime-avibactam and carbapenems. Genetic analysis revealed that blaKPC-204 located on highly mobile IncFII/IncR plasmid within complex genetic structure facilitates its spread. Functional analysis, achieved through cloning into E. coli DH5α, validates KPC-204's contribution increased ceftazidime-avibactam. The kinetic parameters showed exhibited similar affinity KPC-2 toward ceftazidime reduced sensitivity avibactam. Mating experiments demonstrated the resistance's transmissibility. investigation underscores evolving diversity KPC variants affecting resistance, highlighting necessity for continuous monitoring.

Language: Английский

Citations

1